GSK 6853

Name: GSK 6853
Brand: Tocris Bioscience
SKU: 6198

Tocris Bioscience, part of Bio-Techne | Catalog # 6198

COA / SDS

Potent and selective BRPF1 inhibitor

Key Product Details

Description:	Potent and selective BRPF1 inhibitor
Chemical Name:	N-[2,3-dihydro-1,3-dimethyl-6-[(2R)-2-methyl-1-piperazinyl]-2-oxo-1H-benzimidazol-5-yl]-2-methoxybenzamide
Purity:	≥98% (HPLC)
Molecular Weight:	409.48

View Full Technical Details for GSK 6853

Technical Data
Citations

Biological Activity for GSK 6853

GSK 6853 is a potent and selective BRPF1 inhibitor. Exhibits >1600-fold selectivity for BRPF1 over other bromodomains (pIC₅₀ values by TR-FRET are 8.1, 5.1/4.8 and 4.7/<4.3 for BRPF1, BRPF2/3 and BRD4 BD1/2, respectively).

Negative Control also available.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the GSK 6853 probe summary on the SGC website.

Compound Libraries for GSK 6853

GSK 6853 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for GSK 6853

M. Wt	409.48
Formula	C₂₂H₂₇N₅O₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1910124-24-1
PubChem ID	121232405
InChi Key	FQWDVNSBYDXPIO-CQSZACIVSA-N
Smiles	COC1=C(C(NC2=C(N3CCNC[C@H]3C)C=C4N(C(N(C4=C2)C)=O)C)=O)C=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for GSK 6853

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	40.95	100
	1eq. HCl	40.95	100

Preparing Stock Solutions for GSK 6853

The following data is based on the product molecular weight 409.48.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.44 mL	12.21 mL	24.42 mL
5 mM	0.49 mL	2.44 mL	4.88 mL
10 mM	0.24 mL	1.22 mL	2.44 mL
50 mM	0.05 mL	0.24 mL	0.49 mL

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Reconstitution Calculator

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References for GSK 6853

References are publications that support the biological activity of the product.

Bamborough GSK6853, a chemical probe for inhibition of the BRPF1 bromodomain. ACS Med.Chem.Lett. 2016 PMID: 27326325