GSK J4

Name: GSK J4
Brand: Tocris Bioscience
SKU: 4594
Rating: 5 (2 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 4594

(2)

Citations (52)

COA / SDS

Histone KDM inhibitor; cell permeable

Key Product Details

Chemical Name:	N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-β-alanine ethyl ester
Purity:	≥99%

View Full Technical Details for GSK J4

Technical Data
Citations / Reviews (2)

Biological Activity for GSK J4

GSK J4 is a histone lysine demethylase (KDM) inhibitor; blocks demethylation of histone H3K27. Attenuates lipopolysaccharide (LPS)-induced proinflammatory cytokine production in primary human macrophages (IC₅₀ = 9 μM for the inhibition of TNFα release). Cell permeable. Ethyl ester derivative of GSK J1.

Negative Control also available.

Technical Data for GSK J4

Formula	C₂₄H₂₇N₅O₂
Storage	Store at RT
Purity	≥99%
CAS Number	1373423-53-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for GSK J4

Solubility

Soluble Soluble to 100 mM in DMSO and to 100 mM in ethanol

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References for GSK J4

References are publications that support the biological activity of the product.

S Petruk, SA Mariani, M De Dominic, P Porazzi, V Minieri, J Cai, L Iacovitti, N Flomenberg, B Calabretta, A Mazo Structure of Nascent Chromatin Is Essential for Hematopoietic Lineage Specification Cell Rep, 2017;19(2):295-306. 2017 PMID: 28402853
Gallagher K, Joshi A, Carson W, Schaller M, Allen R, Mukerjee S, Kittan N, Feldman E, Henke P, Hogaboam C, Burant C, Kunkel S Epigenetic changes in bone marrow progenitor cells influence the inflammatory phenotype and alter wound healing in type 2 diabetes. Diabetes, 2015;64(4):1420-30. 2015 PMID: 25368099
Heinemann et al. Inhibition of demethylases by GSK-J1/J4. Nature, 2014;514:E1 PMID: 25279926
Kruidenier et al. A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response. Nature, 2012;488:404 PMID: 22842901

GSK J4

Tocris Bioscience, part of Bio-Techne | Catalog # 4594

Key Product Details

Biological Activity for GSK J4

Technical Data for GSK J4

Solubility for GSK J4

Dilution Calculator

Reconstitution Calculator

References for GSK J4

Product Documents for GSK J4

COA

Certificate of Analysis

SDS

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