GW 3965 hydrochloride

Name: GW 3965 hydrochloride
Brand: Tocris Bioscience
SKU: 2474

Tocris Bioscience, part of Bio-Techne | Catalog # 2474

Citations (13)

COA / SDS

Orally active liver X receptor (LXR) agonist

Key Product Details

Description:	Orally active liver X receptor (LXR) agonist
Chemical Name:	3-[3-[[[2-Chloro-3-(trifluoromethyl)phenyl]methyl](2,2-diphenylethyl)amino]propoxy]benzeneacetic acid hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	618.51

View Full Technical Details for GW 3965 hydrochloride

Technical Data
Citations

Biological Activity for GW 3965 hydrochloride

GW 3965 hydrochloride is a selective, orally active non-steroidal agonist for the liver X receptor (LXR). In cell-based reporter gene assays, acts as a full agonist of hLXRα and hLXRβ (EC₅₀ values are 190 and 30 nM respectively). Reduces angiotensin II-mediated increases in blood pressure; up-regulates ABCA1 gene expression and raises circulating HDL levels. Displays potent antiatherogenic activity in mouse models of atherosclerosis.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Compound Libraries for GW 3965 hydrochloride

GW 3965 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for GW 3965 hydrochloride

M. Wt	618.51
Formula	C₃₃H₃₁NO₃ClF₃.HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	405911-17-3
PubChem ID	16078973
InChi Key	NMPUWJFHNOUNQU-UHFFFAOYSA-N
Smiles	Cl.OC(=O)CC1=CC=CC(OCCCN(CC(C2=CC=CC=C2)C2=CC=CC=C2)CC2=C(Cl)C(=CC=C2)C(F)(F)F)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for GW 3965 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	61.85	100
	ethanol	12.37	20

Preparing Stock Solutions for GW 3965 hydrochloride

The following data is based on the product molecular weight 618.51.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.62 mL	8.08 mL	16.17 mL
5 mM	0.32 mL	1.62 mL	3.23 mL
10 mM	0.16 mL	0.81 mL	1.62 mL
50 mM	0.03 mL	0.16 mL	0.32 mL

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References for GW 3965 hydrochloride

References are publications that support the biological activity of the product.

Leik GW3965, a synthetic liver X receptor (LXR) agonist, reduces angiotensin II-mediated pressor responses in Sprague-Dawley rats. Br.J.Pharmacol. 2007 PMID: 17420776
Joseph Synthetic LXR ligand inhibits the development of atherosclerosis in mice Proc.Natl.Acad.Sci.USA
Collins Identification of a nonsteroidal liver X receptor agonist through parallel array synthesis of tertiary amines. J.Med.Chem. 2002 PMID: 11985463