GW 9508

Tocris Bioscience, part of Bio-Techne | Catalog # 2649

COA / SDS

Potent and selective FFA1 (GPR40) agonist

Key Product Details

Description:	Potent and selective FFA1 (GPR40) agonist
Chemical Name:	4-[[(3-Phenoxyphenyl)methyl]amino]benzenepropanoic acid
Purity:	≥99% (HPLC)
Molecular Weight:	347.41

View Full Technical Details for GW 9508

Technical Data
Citations

Biological Activity for GW 9508

GW 9508 is a potent and selective agonist for the free fatty acid receptor FFA1 (GPR40) (pEC₅₀ values are 7.32, < 4.3 and < 4.3 for FFA1, FFA2 and FFA3 receptors respectively). Inactive against a range of other GPCRs, kinases, proteases, integrins and PPARs. Potentiates glucose-stimulated insulin secretion in MIN6 cells (pEC₅₀ = 6.14).

Licensing Information

Sold with the permission of GlaxoSmithKline

Compound Libraries for GW 9508

GW 9508 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for GW 9508

M. Wt	347.41
Formula	C₂₂H₂₁NO₃
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	885101-89-3
PubChem ID	11595431
InChi Key	DGENZVKCTGIDRZ-UHFFFAOYSA-N
Smiles	OC(=O)CCC1=CC=C(NCC2=CC=CC(OC3=CC=CC=C3)=C2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for GW 9508

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	34.74	100
	ethanol	34.74	100

Preparing Stock Solutions for GW 9508

The following data is based on the product molecular weight 347.41.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.88 mL	14.39 mL	28.78 mL
5 mM	0.58 mL	2.88 mL	5.76 mL
10 mM	0.29 mL	1.44 mL	2.88 mL
50 mM	0.06 mL	0.29 mL	0.58 mL

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Reconstitution Calculator

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References for GW 9508

References are publications that support the biological activity of the product.

Briscoe Pharmacological regulation of Ins secretion in MIN6 cells through fatty acid receptor GPR40: identification of agonist and antagonist small molecules. Br.J.Pharmacol. 2006 PMID: 16702987
Zhao and Chen Activation of ATP-sensitive potassium channels in rat pancreatic β-cells by linoleic acid through both intracellular metabolites and membrane receptor signalling pathway. J.Endocrinol. 2008 PMID: 18550787
Garrido Synthesis and activity of small molecule GPR40 agonists. Bioorg.Med.Chem.Lett. 2006 PMID: 16439116