H2L 5765834

Name: H2L 5765834
Brand: Tocris Bioscience
SKU: 4870
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 4870

(1)

Citations (6)

COA / SDS

LPA1,3,5 antagonist

Discontinued Product

4870 has been discontinued. View all Lysophosphatidic Acid (LPA) Receptor Antagonists products.

Key Product Details

Description:	LPA_1,3,5 antagonist
Chemical Name:	2,3-Dihydro-2-[3-(4-nitrophenoxy)phenyl]-1,3-dioxo-1H-isoindole-5-carboxylic acid
Purity:	≥99% (HPLC)
Molecular Weight:	404.33

View Full Technical Details for H2L 5765834

Technical Data
Citations / Reviews (1)

Biological Activity for H2L 5765834

H2L 5765834 is an antagonist of the lysophosphatidic acid receptors LPA₁, LPA₅ and LPA₃ (IC₅₀ values are 94, 463 and 752 nM respectively). Exhibits no effect at LPA₂ or LPA₄ receptors.

Compound Libraries for H2L 5765834

H2L 5765834 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for H2L 5765834

M. Wt	404.33
Formula	C₂₁H₁₂N₂O₇
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	420841-84-5
PubChem ID	1365686
InChi Key	HFYPTENHTPNXGP-UHFFFAOYSA-N
Smiles	O=C2N(C3=CC=CC(OC4=CC=C([N+]([O-])=O)C=C4)=C3)C(C1=CC(C(O)=O)=CC=C12)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for H2L 5765834

References are publications that support the biological activity of the product.

Fells 2D binary QSAR modeling of LPA₃ receptor antagonism. J.Mol.Graph Model. 2010 PMID: 20356772
Tigyi Aiming drug discovery at lysophosphatidic acid targets. Br.J.Pharmacol. 2010 PMID: 20735414
Williams Unique ligand selectivity of the GPR92/LPA₅ lysophosphatidate receptor indicates role in human platelet activation. J.Biol.Chem. 2009 PMID: 19366702