Haloperidol hydrochloride

Name: Haloperidol hydrochloride
Brand: Tocris Bioscience
SKU: 0931
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 0931

(1)

Citations (32)

COA / SDS

Dopamine antagonist; displays some D2 selectivity

Key Product Details

Description:	Dopamine antagonist; displays some D₂ selectivity
Chemical Name:	4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-1-butanone hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	412.33

View Full Technical Details for Haloperidol hydrochloride

Technical Data
Citations / Reviews (1)

Biological Activity for Haloperidol hydrochloride

Haloperidol hydrochloride is a dopamine antagonist with selectivity for D₂-like receptors (K_i values are 1.2, ~ 7, 2.3, ~ 80 and ~ 100 nM for D₂, D₃, D₄, D₁ and D₅ receptors respectively). Subtype-selective NMDA antagonist. Identified as targeting human host proteins that interact with SARS-CoV-2.

Technical Data for Haloperidol hydrochloride

M. Wt	412.33
Formula	C₂₁H₂₃ClFNO₂.HCl
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	1511-16-6
PubChem ID	11495267
InChi Key	JMRYYMBDXNZQMH-UHFFFAOYSA-N
Smiles	Cl.OC1(CCN(CCCC(=O)C2=CC=C(F)C=C2)CC1)C1=CC=C(Cl)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Haloperidol hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	10.31	25 with gentle warming

Preparing Stock Solutions for Haloperidol hydrochloride

The following data is based on the product molecular weight 412.33.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	9.70 mL	48.50 mL	97.01 mL
1.25 mM	1.94 mL	9.70 mL	19.40 mL
2.5 mM	0.97 mL	4.85 mL	9.70 mL
12.5 mM	0.19 mL	0.97 mL	1.94 mL

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Reconstitution Calculator

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References for Haloperidol hydrochloride

References are publications that support the biological activity of the product.

Gordon A SARS-CoV-2 protein-protein interaction map reveals drug targets and drug repurposing. Nature 2020 PMID: 32353859
Seeman and Van Tol DA receptor pharmacology. TiPS 1994 PMID: 7940991
IIyin Subtype-selective inhibition of N-MthD.-aspartate receptors by halope. Mol.Pharmacol. 1996 PMID: 8967976
Lynch and Gallagher Inhibition of N-MthD.-aspartate receptors by haloperidol: development and pharmacological characterization in native and recombinant receptors. J.Pharmacol.Exp.Ther. 1996 PMID: 8858988
Beresford and Ward Haloperidol decanoate. A preliminary review of its pharmacodynamic and pharmacokinetic properties and therapeutic use in psychosis. Drugs 1987 PMID: 3545764

Product Documents for Haloperidol hydrochloride

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.

SDS

⚠ WARNING: This product can expose you to chemicals including Haloperidol, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov