Harmine

Name: Harmine
Brand: Tocris Bioscience
SKU: 5075

Tocris Bioscience, part of Bio-Techne | Catalog # 5075

Citations (7)

COA / SDS

Potent and selective DYRK1A inhibitor

Key Product Details

Chemical Name:	7-Methoxy-1-methyl-9H-pyrido[3,4-b]indole
Purity:	≥98%

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Technical Data
Citations

Biological Activity for Harmine

Harmine is a potent and selective inhibitor of DYRK1A (IC₅₀ values are 80, 800 and 900 nM for DYRK1A, DYRK3 and DYRK2 respectively). Inhibits DYRK1A-mediated tau phosphorylation and regulates PPARγ expression. Harmine also induces pancreatic β cell proliferation and exhibits antidiabetic activity. Orally bioavailable. Harmine has high affinity (K_d = 100 nM) for the yjdF aptamer. The riboswitch function of yjdF motif RNAs is activated by Harmine and leads to robust reporter gene expressions in B. subtilis.

Technical Data for Harmine

Formula	C₁₃H₁₂N₂O
Storage	Store at RT
Purity	≥98%
CAS Number	442-51-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Harmine

Solubility

Soluble Soluble to 100 mM in DMSO and to 5 mM in ethanol with gentle warming

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References for Harmine

References are publications that support the biological activity of the product.

Smith et al. Recent advances in the design, synthesis, and biological evaluation of selective DYRK1A inhibitors: a new avenue for a disease modifying treatment of Alzheimer's? ACS Chem.Neurosci., 2012;3:857 PMID: 23173067
Bain et al. The selectivity of protein kinase inhibitors: a further update. Biochem.J., 2007;408:297 PMID: 17850214
Wang et al. A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replication. Nat.Med., 2015;21:383 PMID: 25751815
Waki et al. The small molecule harmine is an antidiabetic cell-type-specific regulator of PPARγ expression. Cell Metab., 2007;5:357 PMID: 17488638

Harmine

Tocris Bioscience, part of Bio-Techne | Catalog # 5075

Key Product Details

Biological Activity for Harmine

Technical Data for Harmine

Solubility for Harmine

Dilution Calculator

Reconstitution Calculator

References for Harmine

Product Documents for Harmine

COA

Certificate of Analysis

SDS

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