Heclin

Name: Heclin
Brand: Tocris Bioscience
SKU: 5433

Tocris Bioscience, part of Bio-Techne | Catalog # 5433

Citations (12)

COA / SDS

HECT E3 ubiquitin ligase inhibitor

Key Product Details

Description:	HECT E3 ubiquitin ligase inhibitor
Chemical Name:	N-(4-Acetylphenyl)-3-(5-ethyl-2-furanyl)-2-propenamide
Purity:	≥98% (HPLC)
Molecular Weight:	283.32

View Full Technical Details for Heclin

Technical Data
Citations

Biological Activity for Heclin

Heclin is a HECT E3 ubiquitin ligase inhibitor; inhibits Nedd4, Smurf2 and WWP1 (IC₅₀ values are 6.3, 6.8 and 6.9 μM respectively). Selective for HECT-mediated over RING-mediated ubiquitination.

Compound Libraries for Heclin

Heclin is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for Heclin

M. Wt	283.32
Formula	C₁₇H₁₇NO₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	890605-54-6
PubChem ID	7464118
InChi Key	SPTWXRJNCFIDRQ-ZHACJKMWSA-N
Smiles	CC(C1=CC=C(NC(/C=C/C2=CC=C(CC)O2)=O)C=C1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Heclin

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	28.33	100
	ethanol	14.17	50

Preparing Stock Solutions for Heclin

The following data is based on the product molecular weight 283.32.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.53 mL	17.65 mL	35.30 mL
5 mM	0.71 mL	3.53 mL	7.06 mL
10 mM	0.35 mL	1.76 mL	3.53 mL
50 mM	0.07 mL	0.35 mL	0.71 mL

Molarity Calculator

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Reconstitution Calculator

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References for Heclin

References are publications that support the biological activity of the product.

Mund Peptide and small molecule inhibitors of HECT-type ubiquitin ligases. Proc.Natl.Acad.Sci.U.S.A. 2014 PMID: 25385595