HEMADO

Tocris Bioscience, part of Bio-Techne | Catalog # 1579

COA / SDS

High affinity selective A3 agonist

Key Product Details

Description:	High affinity selective A₃ agonist
Chemical Name:	2-(1-Hexynyl)-N-methyladenosine
Purity:	≥99% (HPLC)
Molecular Weight:	361.4

View Full Technical Details for HEMADO

Technical Data
Citations

Biological Activity for HEMADO

HEMADO is a high affinity and selective adenosine A₃ receptor agonist (K_i values are 1.1, 327, 1230 and > 30,000 nM for human A₃, A₁, A_2A and A_2B receptors respectively).

Compound Libraries for HEMADO

HEMADO is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for HEMADO

M. Wt	361.4
Formula	C₁₇H₂₃N₅O₄
Storage	Desiccate at +4°C
Purity	≥99% (HPLC)
CAS Number	403842-38-6
PubChem ID	10981286
InChi Key	KOCIMZNSNPOGOP-IWCJZZDYSA-N
Smiles	O[C@@H]1[C@@H](CO)O[C@@H](N(C=N3)C2=C3C(NC)=NC(C#CCCCC)=N2)[C@@H]1O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for HEMADO

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	36.14	100
	DMSO	36.14	100

Preparing Stock Solutions for HEMADO

The following data is based on the product molecular weight 361.4.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.77 mL	13.84 mL	27.67 mL
5 mM	0.55 mL	2.77 mL	5.53 mL
10 mM	0.28 mL	1.38 mL	2.77 mL
50 mM	0.06 mL	0.28 mL	0.55 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for HEMADO

References are publications that support the biological activity of the product.

Volpini N⁶-Alkyl-2-alkynyl derivatives of adenosine as potent and selective agonists at the human adenosine A₃ receptor and a starting point for searching A_2B ligands J.Med.Chem. 2002 PMID: 12109910
Klotz [³H]HEMADO- a novel tritated agonist selective for the human adenosine A₃-receptor. Eur.J.Pharmacol. 2006 PMID: 17126322