HLI 373

Name: HLI 373
Brand: Tocris Bioscience
SKU: 3503

Tocris Bioscience, part of Bio-Techne | Catalog # 3503

Citations (4)

COA / SDS

Hdm2 inhibitor; activates p53-dependent transcription

Key Product Details

Description:	Hdm2 inhibitor; activates p53-dependent transcription
Chemical Name:	5-[[3-Dimethylamino)propyl]amino]-3,10-dimethylpyrimido[4,5-b]quinoline-2,4(3H,10H)-dione dihydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	414.33

View Full Technical Details for HLI 373

Technical Data
Citations

Biological Activity for HLI 373

HLI 373 is an inhibitor of Hdm2 ubiquitin ligase (E3). Blocks Hdm2-mediated ubiquitylation and proteasomal degradation of p53; activates p53-dependent transcription. Induces apoptosis in several tumor cell lines that express wild-type p53 such as LOX-IMVI, A549, HT1080 and U2OS.

Compound Libraries for HLI 373

HLI 373 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for HLI 373

M. Wt	414.33
Formula	C₁₈H₂₃N₅O₂.2HCl
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	1782531-99-0
PubChem ID	72193867
InChi Key	WUEMKAQTAIRDOA-UHFFFAOYSA-N
Smiles	CN2C1=CC=CC=C1C(NCCCN(C)C)=C3C2=NC(N(C)C3=O)=O.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for HLI 373

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	37.79	100
	DMSO	3.78	10

Preparing Stock Solutions for HLI 373

The following data is based on the product molecular weight 414.33.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.41 mL	12.07 mL	24.14 mL
5 mM	0.48 mL	2.41 mL	4.83 mL
10 mM	0.24 mL	1.21 mL	2.41 mL
50 mM	0.05 mL	0.24 mL	0.48 mL

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References for HLI 373

References are publications that support the biological activity of the product.

Yang Targeting the ubiquitin-proteasome system for cancer therapy. Cancer Sci. 2009 PMID: 19037995
Kitagaki Targeting tumor cells expressing p53 with a water-soluble inhibitor of Hdm2. Mol.Cancer Ther. 2008 PMID: 18723490