HU 308

Tocris Bioscience, part of Bio-Techne | Catalog # 3088

COA / SDS

Potent and selective CB2 agonist

Key Product Details

Description:	Potent and selective CB₂ agonist
Chemical Name:	(1S,4S,5S)-4-[4-(1,1-Dimethylheptyl)-2,6-dimethoxyphenyl]-6,6-dimethylbicyclo[3.1.1]hept-2-ene-2-methanol
Purity:	≥98% (HPLC)
Molecular Weight:	414.62

View Full Technical Details for HU 308

Technical Data
Citations

Biological Activity for HU 308

HU 308 is a potent and selective CB₂ receptor agonist (K_i values are 22.7 nM and > 10 μM for CB₂ and CB₁ receptors respectively, EC₅₀ = 5.57 nM). Displays antiallodynic activity in the rat hindpaw incision model of postoperative pain. Also neuroprotective and improves motor performance in a mouse model of Huntington's Disease.

Technical Data for HU 308

M. Wt	414.62
Formula	C₂₇H₄₂O₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	256934-39-1
PubChem ID	11553430
InChi Key	CFMRIVODIXTERW-BDTNDASRSA-N
Smiles	CCCCCCC(C)(C)C1=CC(OC)=C([C@]2([H])[C@H](C3)C(C)(C)[C@H]3C(CO)=C2)C(OC)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for HU 308

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	41.46	100
	ethanol	41.46	100

Preparing Stock Solutions for HU 308

The following data is based on the product molecular weight 414.62.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.41 mL	12.06 mL	24.12 mL
5 mM	0.48 mL	2.41 mL	4.82 mL
10 mM	0.24 mL	1.21 mL	2.41 mL
50 mM	0.05 mL	0.24 mL	0.48 mL

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Reconstitution Calculator

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References for HU 308

References are publications that support the biological activity of the product.

Hanus HU-308: a specific agonist for CB₂, a peripheral cannabinoid receptor. Proc.Natl.Acad.Sci.USA 1999 PMID: 10588688
Palazuelos Microglial CB₂ cannabinoid receptors are neuroprotective in Huntington's disease excitotoxicity. Brain 2009 PMID: 19805493
LaBuda Cannabinoid CB₂ receptor agonist activity in the hindpaw incision model of postoperative pain. Eur.J.Pharmacol. 2005 PMID: 16316653