Ibudilast

Name: Ibudilast
Brand: Tocris Bioscience
SKU: 1694

Tocris Bioscience, part of Bio-Techne | Catalog # 1694

Citations (3)

COA / SDS

PDE inhibitor (non-selective)

Key Product Details

Description:	PDE inhibitor (non-selective)
Alternative Names:	KC-404
Chemical Name:	2-Methyl-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl]-1-propanone
Purity:	≥98% (HPLC)
Molecular Weight:	230.31

View Full Technical Details for Ibudilast

Technical Data
Citations

Biological Activity for Ibudilast

Ibudilast is a phosphodiesterase inhibitor (IC₅₀ values are 53, 35, 48, 12 and 10 μM for PDE Ia, II, III, IV and V respectively). Inhibits platelet aggregation and is an orally-active cerebral vasodilator, bronchodilator and antiallergic agent.

Compound Libraries for Ibudilast

Ibudilast is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Ibudilast

M. Wt	230.31
Formula	C₁₄H₁₈N₂O
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	50847-11-5
PubChem ID	3671
InChi Key	ZJVFLBOZORBYFE-UHFFFAOYSA-N
Smiles	CC(C)C(=O)C1=C2C=CC=CN2N=C1C(C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Ibudilast

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	23.03	100
	ethanol	23.03	100

Preparing Stock Solutions for Ibudilast

The following data is based on the product molecular weight 230.31.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.34 mL	21.71 mL	43.42 mL
5 mM	0.87 mL	4.34 mL	8.68 mL
10 mM	0.43 mL	2.17 mL	4.34 mL
50 mM	0.09 mL	0.43 mL	0.87 mL

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Reconstitution Calculator

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References for Ibudilast

References are publications that support the biological activity of the product.

Nishino KC-404: a potential anti-allergic agent with antagonistic action against slow reacting substance of anaphylaxis. Jpn.J.Pharmacol. 1983 PMID: 6193303
Souness Possible role of cyclic AMP phosphodiesterases in the actions of ibudilast on eosinophil thromboxane generation and airways smooth muscle tone. Br.J.Pharmacol. 1994 PMID: 8032594
Kishi Ibudilast: a non-selective PDE inhibitor with multiple actions on blood cells and the vascular wall. Cardiovasc.Drug Rev. 2001 PMID: 11607039