iCRT 14

Name: iCRT 14
Brand: Tocris Bioscience
SKU: 4299

Tocris Bioscience, part of Bio-Techne | Catalog # 4299

(1)

Citations (30)

COA / SDS

Inhibits β-catenin-responsive transcription (CRT)

Key Product Details

Chemical Name:	5-[[2,5-Dimethyl-1-(3-pyridinyl)-1H-pyrrol-3-yl]methylene]-3-phenyl-2,4-thiazolidinedion
Purity:	≥98%
Molecular Weight:	375.44 kDa

View Full Technical Details for iCRT 14

Technical Data
Citations / Reviews (1)

Biological Activity for iCRT 14

iCRT 14 is a potent inhibitor of β-catenin-responsive transcription (CRT) (IC₅₀ = 40.3 nM in assays of Wnt pathway activity). Thought to directly influence the interaction between β-catenin and TCF4. Induces marked G₀/G₁ cell cycle arrest in HCT-116 and HT29 cell lines. Also acts as transfection enhancer; enhances transgene expression in PC-3 cells by 16 to 35-fold using nonviral systems.

Technical Data for iCRT 14

M. Wt	375.44 kDa
Formula	C₂₁H₁₇N₃O₂S
Storage	Store at +4°C
Purity	≥98%
CAS Number	677331-12-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for iCRT 14

Solubility

Soluble Soluble to 75 mM in DMSO

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References for iCRT 14

References are publications that support the biological activity of the product.

Rotherham M, El Haj A Remote activation of the Wnt/beta-catenin signalling pathway using functionalised magnetic particles. PLoS ONE, 2015;10(3):e0121761. 2015 PMID: 25781466
Mathur R, Sehgal L, Braun F, Berkova Z, Romaguerra J, Wang M, Rodriguez M, Fayad L, Neelapu S, Samaniego F Targeting Wnt pathway in mantle cell lymphoma-initiating cells. J Hematol Oncol, 2015;8(0):63. 2015 PMID: 26048374
BA Brown, GM Connolly, CEJ Mill, H Williams, GD Angelini, JL Johnson, SJ George Aging differentially modulates the Wnt pro-survival signalling pathways in vascular smooth muscle cells Aging Cell, 2018;0(0):e12844. 2018 PMID: 30548452
Spivack et al. Enhancement of transgene expression by the β-catenin inhibitor iCRT14. Plasmid, 2021; PMID: 33472046