IDE 1

Name: IDE 1
Brand: Tocris Bioscience
SKU: 4015

Tocris Bioscience, part of Bio-Techne | Catalog # 4015

Citations (8)

COA / SDS

Induces definitive endoderm formation in mouse and human ESCs

Key Product Details

Chemical Name:	1-[2-[(2-Carboxyphenyl)methylene]hydrazide]heptanoic acid
Purity:	≥98%
Molecular Weight:	306.31 kDa

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Technical Data
Citations

Biological Activity for IDE 1

IDE 1 is an induces definitive endoderm formation in mouse and human embryonic stem cells (ESCs) (EC₅₀ = 125 nM). Thought to activate the TGF-β signaling pathway; induces Smad2 phosphorylation and increases levels of Nodal expression.

This compound is mixture of E/Z isomers.

Technical Data for IDE 1

M. Wt	306.31 kDa
Formula	C₁₅H₁₈N₂O₅
Storage	Store at +4°C
Purity	≥98%
CAS Number	1160927-48-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for IDE 1

Solubility

Soluble Soluble to 100 mM in 2eq. NaOH and to 100 mM in DMSO

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References for IDE 1

References are publications that support the biological activity of the product.

Borowiak M, Maehr R, Chen S, Chen AE, Tang W, Fox JL, Schreiber SL, Melton DA Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells. Cell Stem Cell, 2009-04-03;4(4):348-58. 2009-04-03 PMID: 19341624
Zaret Using small molecules to great effect in stem cell differentiation. Cell Stem Cell, 2009;4:373 PMID: 19427285
Filby et al. Stimulation of AVNA/Nodal signaling is insufficient to induce definitive endoderm formation of cord blood-derived unrestricted somatic stem cells. Stem Cell Res.Ther., 2011;2:16 PMID: 21463501