IDR 1002

Name: IDR 1002
Brand: Tocris Bioscience
SKU: 7866

Tocris Bioscience, part of Bio-Techne | Catalog # 7866

COA / SDS

Innate defence regulator peptide

Key Product Details

Description:	Innate defence regulator peptide
Purity:	≥95% (HPLC)
Molecular Weight:	1652.06

View Full Technical Details for IDR 1002

Technical Data
Citations

Biological Activity for IDR 1002

IDR 1002 is an innate defence regulator peptide. It reduces bacterial burden and inflammatory responses in murine models of sinusitis infection and bacterial acute lung infection. It inhibits LPS-induced NF-κB and COX-2 and induces the phosphorylation/activation of p38, ERK1/2, MSK1, and CREB.

Technical Data for IDR 1002

M. Wt	1652.06
Formula	C₇₉H₁₃₀N₂₆O₁₃
Single Letter Sequence	VQRWLIVWRIRK Modifications: Lys-12; C-terminal amide)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	1224095-25-3
PubChem ID	166603919
InChi Key	SEBZWKNTKRJFDZ-BRVBZNILSA-N
Smiles	O=C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC1=CNC2=CC=CC=C12)C(N[C@@H](CC(C)C)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](C(C)C)C(N[C@@H](CC3=CNC4=CC=CC=C34)C(N[C@@H](CCCNC(N)=N)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](C(C)C)N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for IDR 1002

Solubility

Soluble to 1mg/ml in water

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References for IDR 1002

References are publications that support the biological activity of the product.

Wuerth Characterization of host responses during pseudomonas aeruginosa acute infection in the lungs and blood and after treatment with the synthetic immunomodulatory peptide IDR-1002. Infect.Immun. 2018 PMID: 30323028
Huante-Mendoza Peptide IDR-1002 inhibits NF-κB nuclear translocation by inhibition of IκBα degradation and activates p38/ERK1/2-MSK1-dependent CREB phosphorylation in macrophages stimulated with lipopolysaccharide. Front.Immunol. 2016 PMID: 27933067
Alford Murine model of sinusitis infection for screening antimicrobial and immunomodulatory therapies. Front.Cell.Infect.Microbiol. 2021 PMID: 33777834