IMD 0354

Name: IMD 0354
Brand: Tocris Bioscience
SKU: 2611
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 2611

(1)

Citations (24)

COA / SDS

Inhibitor of IKKβ; also exhibits antibacterial activity

Key Product Details

Description:	Inhibitor of IKKβ; also exhibits antibacterial activity
Chemical Name:	N-[3,5-Bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide
Purity:	≥99% (HPLC)
Molecular Weight:	383.67

View Full Technical Details for IMD 0354

Technical Data
Citations / Reviews (1)

Biological Activity for IMD 0354

IMD 0354 is an inhibitor of IκB kinase-β (IKKβ) that blocks NF-κB nuclear translocation. Attenuates myocardial ischemia/reperfusion injury by decreasing expression of adhesion molecules ICAM-1 and P-selectin and inhibiting cytokine and chemokine production in cardiomyocytes. Induces G₀/G₁ cell cycle arrest and apoptosis in HMC-1 and breast cancer cells. Antagonist at P2X₁, P2X₄ and P2X₇ receptors (IC₅₀ values are 19, 156 and 175 nM respectively). Inhibits platelet aggregation induced by collagen in vitro. Exhibits potent antibacterial activity against MRSA in C. elegans model (MIC = 0.06 μg/mL). Selective aquaporin 4 inhibitor (IC₅₀ values are 210 nM, 390 nM and 420 nM at rat, mouse and human receptors, respectively).

Technical Data for IMD 0354

M. Wt	383.67
Formula	C₁₅H₈ClF₆NO₂
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	978-62-1
PubChem ID	5081913
InChi Key	CHILCFMQWMQVAL-UHFFFAOYSA-N
Smiles	OC1=C(C=C(Cl)C=C1)C(=O)NC1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for IMD 0354

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	38.36	100
	ethanol	38.36	100

Preparing Stock Solutions for IMD 0354

The following data is based on the product molecular weight 383.67.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.61 mL	13.03 mL	26.06 mL
5 mM	0.52 mL	2.61 mL	5.21 mL
10 mM	0.26 mL	1.30 mL	2.61 mL
50 mM	0.05 mL	0.26 mL	0.52 mL

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References for IMD 0354

References are publications that support the biological activity of the product.

Escobar New antimicrobial bioactivity against multidrug resistant gram-positive bacteria of kinase inhibitor IMD0354. Antibiotics 2020 PMID: 33019726
Tanaka A new IκB kinase β inhibitor prevents human breast cancer progression through negative regulation of cell cycle transition. Cancer Res. 2006 PMID: 16397257
Tanaka A novel NF-κB inhibitor, IMD-0354, supresses neoplastic proliferation of human mast cells with constitutively activated c-kit receptors. Hematopoiesis
Onai Inhibition of IκB phosphorylation in cardiomyocytes attenuates myocardial ischemia/reperfusion injury. Cardiovasc.Res. 2004 PMID: 15194461