IMD 0354

Name: IMD 0354
Brand: Tocris Bioscience
SKU: 2611

Tocris Bioscience, part of Bio-Techne | Catalog # 2611

(1)

Citations (24)

COA / SDS

Inhibitor of IKKβ; also exhibits antibacterial activity

Key Product Details

Chemical Name:	N-[3,5-Bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide
Purity:	≥99%

View Full Technical Details for IMD 0354

Technical Data
Citations / Reviews (1)

Biological Activity for IMD 0354

IMD 0354 is an inhibitor of IκB kinase-β (IKKβ) that blocks NF-κB nuclear translocation. Attenuates myocardial ischemia/reperfusion injury by decreasing expression of adhesion molecules ICAM-1 and P-selectin and inhibiting cytokine and chemokine production in cardiomyocytes. Induces G₀/G₁ cell cycle arrest and apoptosis in HMC-1 and breast cancer cells. Antagonist at P2X₁, P2X₄ and P2X₇ receptors (IC₅₀ values are 19, 156 and 175 nM respectively). Inhibits platelet aggregation induced by collagen in vitro. Exhibits potent antibacterial activity against MRSA in C. elegans model (MIC = 0.06 μg/mL). Selective aquaporin 4 inhibitor (IC₅₀ values are 210 nM, 390 nM and 420 nM at rat, mouse and human receptors, respectively).

Technical Data for IMD 0354

Formula	C₁₅H₈ClF₆NO₂
Storage	Store at +4°C
Purity	≥99%
CAS Number	978-62-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for IMD 0354

Solubility

Soluble Soluble to 100 mM in DMSO and to 100 mM in ethanol

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References for IMD 0354

References are publications that support the biological activity of the product.

Onai et al. Inhibition of IκB phosphorylation in cardiomyocytes attenuates myocardial ischemia/reperfusion injury. Cardiovasc.Res., 2004;63:51 PMID: 15194461
Tanaka et al. A new IκB kinase β inhibitor prevents human breast cancer progression through negative regulation of cell cycle transition. Cancer Res., 2006;66:419 PMID: 16397257
Tanaka et al. A novel NF-κB inhibitor, IMD-0354, supresses neoplastic proliferation of human mast cells with constitutively activated c-kit receptors. Hematopoiesis, 2005;105:2324
Escobar et al. New antimicrobial bioactivity against multidrug resistant gram-positive bacteria of kinase inhibitor IMD0354. Antibiotics, 2020;9:665 PMID: 33019726

IMD 0354

Tocris Bioscience, part of Bio-Techne | Catalog # 2611

Key Product Details

Biological Activity for IMD 0354

Technical Data for IMD 0354

Solubility for IMD 0354

Dilution Calculator

Reconstitution Calculator

References for IMD 0354

Product Documents for IMD 0354

COA

Certificate of Analysis

SDS

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