INCA-6

Name: INCA-6
Brand: Tocris Bioscience
SKU: 2162

Tocris Bioscience, part of Bio-Techne | Catalog # 2162

Citations (10)

COA / SDS

Inhibitor of calcineurin-substrate association

Key Product Details

Chemical Name:	9,10-Dihydro-9,10[1',2']-benzenoanthracene-1,4-dione
Purity:	≥95%
Molecular Weight:	284.31 kDa

View Full Technical Details for INCA-6

Technical Data
Citations

Biological Activity for INCA-6

INCA-6 is an inhibitor of interaction between calcineurin and its substrate nuclear factor of activated T cells (NFAT); blocks at the substrate recognition site but not at the catalytic site (K_d = 0.8 mM). Inhibits NFAT dephosphorylation and nuclear import. Also prevents induction of cytokine mRNAs that are downstream targets of NFAT.

Technical Data for INCA-6

M. Wt	284.31 kDa
Formula	C₂₀H₁₂O₂
Storage	Store at -20°C
Purity	≥95%
CAS Number	3519-82-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for INCA-6

Solubility

Soluble Soluble to 20 mM in DMSO

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References for INCA-6

References are publications that support the biological activity of the product.

AL Gibson, CK Hui Mingal, AT Foote, T Uchimura, M Zhang, L Zeng Wnt7a Inhibits IL-1? Induced Catabolic Gene Expression and Prevents Articular Cartilage Damage in Experimental Osteoarthritis Sci Rep, 2017;7(0):41823. 2017 PMID: 28165497
Roehrl et al. Selective inhibition of calcineurin-NFAT signaling by blocking protein-protein interaction with small organic molecules. Proc.Natl.Acad.Sci.USA, 2004;101:7554