INCB 024360-analog

Name: INCB 024360-analog
Brand: Tocris Bioscience
SKU: 6007

Tocris Bioscience, part of Bio-Techne | Catalog # 6007

COA / SDS

Potent indoleamine 2,3-dioxygenase (IDO) inhibitor

Key Product Details

Description:	Potent indoleamine 2,3-dioxygenase (IDO) inhibitor
Chemical Name:	4-Amino-N'-(3-chloro-4-fluorophenyl)-N-hydroxy-1,2,5-oxadiazole-3-carboximidamide
Purity:	≥99% (HPLC)
Molecular Weight:	271.64

View Full Technical Details for INCB 024360-analog

Technical Data
Citations

Biological Activity for INCB 024360-analog

INCB 024360-analog is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor (IC₅₀ values are 19 and 67 nM in enzymatic activity and HeLa cell assays, respectively). Decreases kynurenine levels in plasma and reduces tumor growth in vivo. Cell membrane permeable.

Compound Libraries for INCB 024360-analog

INCB 024360-analog is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for INCB 024360-analog

M. Wt	271.64
Formula	C₉H₇ClFN₅O₂
Storage	Store at -20°C
Purity	≥99% (HPLC)
CAS Number	914471-09-3
PubChem ID	11978742
InChi Key	MUVQOOPKPBEAJZ-VQHVLOKHSA-N
Smiles	O/N=C(NC1=CC(Cl)=C(F)C=C1)/C2=NON=C2N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for INCB 024360-analog

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	27.16	100
	ethanol	27.16	100

Preparing Stock Solutions for INCB 024360-analog

The following data is based on the product molecular weight 271.64.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.68 mL	18.41 mL	36.81 mL
5 mM	0.74 mL	3.68 mL	7.36 mL
10 mM	0.37 mL	1.84 mL	3.68 mL
50 mM	0.07 mL	0.37 mL	0.74 mL

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References for INCB 024360-analog

References are publications that support the biological activity of the product.

Yue Discovery of potent competitive inhibitors of indoleamine 2,3-dioxygenase with in vivo pharmacodynamic activity and efficacy in a mouse melanoma model. J.Med.Chem. 2009 PMID: 19507862
Dounay Challenges and opportunities in the discovery of new therapeutics targeting the kynurenine pathway. J.Med.Chem. 2015 PMID: 26207924
Weinmann Cancer immunotherapy: selected targets and small-molecule modulators. Chem.Med.Chem. 2016 PMID: 26836578