Indatraline hydrochloride

Name: Indatraline hydrochloride
Brand: Tocris Bioscience
SKU: 1588

Tocris Bioscience, part of Bio-Techne | Catalog # 1588

Citations (1)

COA / SDS

Potent 5-HT uptake inhibitor; also inhibits dopamine and noradrenalin uptake

Key Product Details

Description:	Potent 5-HT uptake inhibitor; also inhibits dopamine and noradrenalin uptake
Alternative Names:	Lu 19-005
Chemical Name:	(1R,3S)-rel-3-(3,4-Dichlorophenyl)-2,3-dihydro-N-methyl-1H-inden-1-amine hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	328.67

View Full Technical Details for Indatraline hydrochloride

Technical Data
Citations

Biological Activity for Indatraline hydrochloride

Indatraline hydrochloride is a potent monoamine uptake inhibitor. Inhibits transporters for 5-HT (SERT), dopamine (DAT) and noradrenaline (NET) (K_i values are 0.42, 1.7 and 5.8 nM respectively). Centrally active following systemic administration in vivo.

Compound Libraries for Indatraline hydrochloride

Indatraline hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Indatraline hydrochloride

M. Wt	328.67
Formula	C₁₆H₁₅Cl₂N.HCl
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	96850-13-4
PubChem ID	10314472
InChi Key	QICQDZXGZOVTEF-MELYUZJYSA-N
Smiles	ClC(C=C3)=C(Cl)C=[C@@]3[C@H]2C1=CC=CC=C1[C@H](NC)C2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Indatraline hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	3.29	10 with gentle warming
	DMSO	32.87	100

Preparing Stock Solutions for Indatraline hydrochloride

The following data is based on the product molecular weight 328.67.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.04 mL	15.21 mL	30.43 mL
5 mM	0.61 mL	3.04 mL	6.09 mL
10 mM	0.30 mL	1.52 mL	3.04 mL
50 mM	0.06 mL	0.30 mL	0.61 mL

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Reconstitution Calculator

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References for Indatraline hydrochloride

References are publications that support the biological activity of the product.

Hyttel and Larsen Neurochemical profile of Lu 19-005, a potent inhibitor of uptake of DA, noradrenaline and serotonin. J.Neurochem. 1985 PMID: 2580950
Negus Effects of the long-acting monoamine reuptake inhibitor indatraline on cocaine self-administration in rhesus monkeys. J.Pharmacol.Exp.Ther. 1999 PMID: 10490887
Gu Design, synthesis, and monoamine transporter binding site affinities of methoxy derivatives of indatraline. J.Med.Chem. 2000 PMID: 11123996