INDY

Name: INDY
Brand: Tocris Bioscience
SKU: 4997

Tocris Bioscience, part of Bio-Techne | Catalog # 4997

Citations (8)

COA / SDS

DYRK1A/B inhibitor

Key Product Details

Chemical Name:	(1Z)-1-(3-Ethyl-5-hydroxy-2(3H)-benzothiazolylidene)-2-propanone
Purity:	≥98%

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Technical Data
Citations

Biological Activity for INDY

INDY is a DYRK1A/B inhibitor (IC₅₀ values are 0.23 and 0.24 μM, for DYRK1B and DYRKA respectively). Binds at the ATP-binding cleft of the enzyme. Reverses aberrant tau-phosphorylation and rescues repressed calcineurin/NFAT signaling. Impairs the self-renewal capacity of subventricular zone neural stem cells. Also available as a prodrug, proINDY (Cat. No. 4998).

Technical Data for INDY

Formula	C₁₂H₁₃NO₂S
Storage	Store at -20°C
Purity	≥98%
CAS Number	1169755-45-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for INDY

Solubility

Soluble Soluble to 100 mM in DMSO

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References for INDY

References are publications that support the biological activity of the product.

Ogawa et al. Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A. Nat.Commun., 2010;1:86 PMID: 20981014
Pozo et al. Inhibition of DYRK1A destabilizes EGFR and reduces EGFR-dependent glioblastoma growth. J.Clin.Invest., 2013;123:2475 PMID: 23635774

INDY

Tocris Bioscience, part of Bio-Techne | Catalog # 4997

Key Product Details

Biological Activity for INDY

Technical Data for INDY

Solubility for INDY

Dilution Calculator

Reconstitution Calculator

References for INDY

Product Documents for INDY

COA

Certificate of Analysis

SDS

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