IRAK3 Degrader 23

Name: IRAK3 Degrader 23
Brand: Tocris Bioscience
SKU: 7983

Tocris Bioscience, part of Bio-Techne | Catalog # 7983

COA / SDS

IRAK3 Degrader (PROTAC®

Key Product Details

Description:	IRAK3 Degrader (PROTAC^®
Chemical Name:	2-(2,6-Dioxo-3-piperidyl)-5-[4-[2-[1-[4-[4-[cis-4-[(5-isopropylpyrrolo[2,1-f][1,2,4]triazin-4-yl)amino]cyclohexyl]-piperazin-1-yl]-4-oxo-butanoyl]-4-piperidyl]ethyl]piperazin-1-yl]-isoindoline-1,3-dione
Purity:	≥98% (HPLC)
Molecular Weight:	878.09

View Full Technical Details for IRAK3 Degrader 23

Technical Data
Citations

Biological Activity for IRAK3 Degrader 23

IRAK3 Degrader 23 is a potent and selective IRAK3 Degrader (PROTAC^®; DC₅₀ = 2 nM; D_max = 98% in THP1 cells and primary macrophages), requires CRBN and IRAK3 binding for Degrader activity. Also inhibits CDK11, CDK8, TRKC and GSG2 (IC₅₀ values are 16 nM, 36 nM, 100 nM and 110 nM respectively).

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Technical Data for IRAK3 Degrader 23

M. Wt	878.09
Formula	C₄₇H₆₃N₁₁O₆
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2712600-00-3
PubChem ID	162366970
InChi Key	ZUODKONSNNHSAJ-AMLBMYBGSA-N
Smiles	O=C1C2=CC(N3CCN(CC3)CCC4CCN(CC4)C(CCC(N5CCN([C@@H]6CC[C@@H](CC6)NC7=NC=NN8C7=C(C(C)C)C=C8)CC5)=O)=O)=CC=C2C(N1C9C(NC(CC9)=O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for IRAK3 Degrader 23

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	87.81	100

Preparing Stock Solutions for IRAK3 Degrader 23

The following data is based on the product molecular weight 878.09.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.14 mL	5.69 mL	11.39 mL
5 mM	0.23 mL	1.14 mL	2.28 mL
10 mM	0.11 mL	0.57 mL	1.14 mL
50 mM	0.02 mL	0.11 mL	0.23 mL

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References for IRAK3 Degrader 23

References are publications that support the biological activity of the product.

Degorce Discovery of proteolysis-targeting chimera molecules that selectively degrade the IRAK3 pseudokinase. J.Med.Chem. 2020 PMID: 32803978