Isoginkgetin

Name: Isoginkgetin
Brand: Tocris Bioscience
SKU: 6483

Tocris Bioscience, part of Bio-Techne | Catalog # 6483

Citations (3)

COA / SDS

Pre-mRNA splicing inhibitor; cell permeable

Key Product Details

Description:	Pre-mRNA splicing inhibitor; cell permeable
Chemical Name:	8-[5-(5,7-Dihydroxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl]-5,7-dihydroxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one
Purity:	≥98% (HPLC)
Molecular Weight:	566.51

View Full Technical Details for Isoginkgetin

Technical Data
Citations

Biological Activity for Isoginkgetin

Isoginkgetin is a pre-mRNA splicing inhibitor (IC₅₀ ~ 30 μM); inhibits major and minor spliceosomes. Suppresses transcriptional elongation. Blocks spliceosome-mediated splicing process at the pre-spliceosome/A complex stage. Does not inhibit CDK9. Inhibits tumor cell invasion. Active in vivo. Cell permeable

Technical Data for Isoginkgetin

M. Wt	566.51
Formula	C₃₂H₂₂O₁₀
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	548-19-6
PubChem ID	5318569
InChi Key	HUOOMAOYXQFIDQ-UHFFFAOYSA-N
Smiles	COC1=CC=C(C2=CC(C3=C(C=C(C(C4=CC(C5=CC(C6=C(C=C(C=C6O5)O)O)=O)=CC=C4OC)=C3O2)O)O)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Isoginkgetin

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	56.65	100

Preparing Stock Solutions for Isoginkgetin

The following data is based on the product molecular weight 566.51.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.77 mL	8.83 mL	17.65 mL
5 mM	0.35 mL	1.77 mL	3.53 mL
10 mM	0.18 mL	0.88 mL	1.77 mL
50 mM	0.04 mL	0.18 mL	0.35 mL

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References for Isoginkgetin

References are publications that support the biological activity of the product.

Szewczak The right tool for the job. Cell 2017 PMID: 28475886
Boswell Total RNA-seq to identify pharmacological effects on specific stages of mRNA synthesis. Nat.Chem.Biol. 2017 PMID: 28263964
O'Brien The biflavonoid isoginkgetin is a general inhibitor of Pre-mRNA splicing. J.Biol.Chem. 2008 PMID: 18826947