IWP 4

Name: IWP 4
Brand: Tocris Bioscience
SKU: 5214
Rating: 4 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 5214

(1)

Citations (35)

COA / SDS

Potent inhibitor of Wnt/β-catenin signaling

Key Product Details

Chemical Name:	N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-3-(2-methoxyphenyl)-4-oxothieno[3,2-d]pyrimidin-2-yl)thio]-acetamide
Purity:	≥98%

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Technical Data
Citations / Reviews (1)

Biological Activity for IWP 4

IWP 4 is a potent inhibitor of Wnt/β-catenin signaling (IC₅₀ = 25 nM). Has minimal effect on Notch and Hedgehog signaling pathways. Induces differentiation of cardiomyocytes from human ESCs and iPSCs.

Technical Data for IWP 4

Formula	C₂₃H₂₀N₄O₃S₃
Storage	Store at +4°C
Purity	≥98%
CAS Number	686772-17-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for IWP 4

Solubility

Soluble Soluble to 1 mM in DMSO

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References for IWP 4

References are publications that support the biological activity of the product.

Lian et al. Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling. Proc.Natl.Acad.Sci.U S A, 2012;109:E1848 PMID: 22645348
Chen et al. Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nat.Chem.Biol., 2009;5:100 PMID: 19125156
Narytnyk et al. Differentiation of human epidermal neural crest stem cells (hEPI-NCSC) into virtually homogenous populations of DArgic neurons. Stem Cell Rev., 2014;10:316 PMID: 24399192
Noor et al. 3D Printing of Personalized Thick and Perfusable Cardiac Patches and Hearts. Adv.Sci.(Weinh), 2019;6:1900344 PMID: 31179230
Hoang et al. Generation of spatial-patterned early-developing cardiac organoids using human pluripotent stem cells. Nat.Protoc., 2018;13:723 PMID: 29543795

IWP 4

Tocris Bioscience, part of Bio-Techne | Catalog # 5214

Key Product Details

Biological Activity for IWP 4

Technical Data for IWP 4

Solubility for IWP 4

Dilution Calculator

Reconstitution Calculator

References for IWP 4

Product Documents for IWP 4

COA

Certificate of Analysis

SDS

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