IWP L6

Name: IWP L6
Brand: Tocris Bioscience
SKU: 4992

Tocris Bioscience, part of Bio-Techne | Catalog # 4992

Citations (5)

COA / SDS

Potent PORCN inhibitor

Key Product Details

Chemical Name:	N-(5-Phenyl-2-pyridinyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]acetamide
Purity:	≥98%

View Full Technical Details for IWP L6

Technical Data
Citations

Biological Activity for IWP L6

IWP L6 is a potent inhibitor of Porcupine (PORCN), a membrane-bound O-acyltransferase (MBOAT) (EC₅₀ = 0.5 nM). Shown to inhibit Wnt-dependent processes such as tailfin regeneration and posterior axis formation in zebrafish; also reduces branching morphogenesis in cultured mouse embryonic kidneys.

Technical Data for IWP L6

Formula	C₂₅H₂₀N₄O₂S₂
Storage	Store at +4°C
Purity	≥98%
CAS Number	1427782-89-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for IWP L6

Solubility

Soluble Soluble to 100 mM in DMSO

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References for IWP L6

References are publications that support the biological activity of the product.

Wang et al. The development of highly potent inhibitors for Porcupine. J.Med.Chem., 2013;56:2700 PMID: 23477365

IWP L6

Tocris Bioscience, part of Bio-Techne | Catalog # 4992

Key Product Details

Biological Activity for IWP L6

Technical Data for IWP L6

Solubility for IWP L6

Dilution Calculator

Reconstitution Calculator

References for IWP L6

Product Documents for IWP L6

COA

Certificate of Analysis

SDS

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