IWP L6

Name: IWP L6
Brand: Tocris Bioscience
SKU: 4992

Tocris Bioscience, part of Bio-Techne | Catalog # 4992

Citations (5)

COA / SDS

Potent PORCN inhibitor

Key Product Details

Description:	Potent PORCN inhibitor
Chemical Name:	N-(5-Phenyl-2-pyridinyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]acetamide
Purity:	≥98% (HPLC)
Molecular Weight:	472.58

View Full Technical Details for IWP L6

Technical Data
Citations

Biological Activity for IWP L6

IWP L6 is a potent inhibitor of Porcupine (PORCN), a membrane-bound O-acyltransferase (MBOAT) (EC₅₀ = 0.5 nM). Shown to inhibit Wnt-dependent processes such as tailfin regeneration and posterior axis formation in zebrafish; also reduces branching morphogenesis in cultured mouse embryonic kidneys.

Technical Data for IWP L6

M. Wt	472.58
Formula	C₂₅H₂₀N₄O₂S₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1427782-89-5
PubChem ID	71601111
InChi Key	QESQGTFWEQMCMH-UHFFFAOYSA-N
Smiles	O=C1C3=C(CCS3)N=C(SCC(NC4=NC=C(C5=CC=CC=C5)C=C4)=O)N1C2=CC=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for IWP L6

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	47.26	100

Preparing Stock Solutions for IWP L6

The following data is based on the product molecular weight 472.58.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.12 mL	10.58 mL	21.16 mL
5 mM	0.42 mL	2.12 mL	4.23 mL
10 mM	0.21 mL	1.06 mL	2.12 mL
50 mM	0.04 mL	0.21 mL	0.42 mL

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References for IWP L6

References are publications that support the biological activity of the product.

Wang The development of highly potent inhibitors for Porcupine. J.Med.Chem. 2013 PMID: 23477365