JNJ 63533054

Name: JNJ 63533054
Brand: Tocris Bioscience
SKU: 5666

Tocris Bioscience, part of Bio-Techne | Catalog # 5666

Citations (1)

COA / SDS

Potent and selective GPR139 agonist

Key Product Details

Description:	Potent and selective GPR139 agonist
Chemical Name:	3-Chloro-N-[2-oxo-2-[[(1S)-1-phenylethyl]amino]ethyl]benzamide
Purity:	≥98% (HPLC)
Molecular Weight:	316.78

View Full Technical Details for JNJ 63533054

Technical Data
Citations

Biological Activity for JNJ 63533054

JNJ 63533054 is a potent and selective GPR139 agonist (EC₅₀ = 16 nM). Selective for GPR139 over a panel of GPCRs, ion channels and transporters, including GPR142. Brain and cell penetrant. Orally bioavailable.

Compound Libraries for JNJ 63533054

JNJ 63533054 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for JNJ 63533054

M. Wt	316.78
Formula	C₁₇H₁₇ClN₂O₂
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	1802326-66-4
PubChem ID	2548547
InChi Key	MWDVCHRYCKXEBY-LBPRGKRZSA-N
Smiles	O=C(CNC(C1=CC=CC(Cl)=C1)=O)N[C@@H](C)C2=CC=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for JNJ 63533054

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	31.68	100
	ethanol	6.34	20

Preparing Stock Solutions for JNJ 63533054

The following data is based on the product molecular weight 316.78.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.16 mL	15.78 mL	31.57 mL
5 mM	0.63 mL	3.16 mL	6.31 mL
10 mM	0.32 mL	1.58 mL	3.16 mL
50 mM	0.06 mL	0.32 mL	0.63 mL

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References for JNJ 63533054

References are publications that support the biological activity of the product.

Dvorak Identification and SAR of glycine benzamides as potent agonists for the GPR139 receptor. ACS Med.Chem.Lett. 2015 PMID: 26396690