JTE 013

Tocris Bioscience, part of Bio-Techne | Catalog # 2392

COA / SDS

S1P2 receptor antagonist

Key Product Details

Description:	S1P₂ receptor antagonist
Chemical Name:	1-[1,3-Dimethyl-4-(2-methylethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]-4-(3,5-dichloro-4-pyridinyl)-semicarbazide
Purity:	≥98% (HPLC)
Molecular Weight:	408.29

View Full Technical Details for JTE 013

Technical Data
Citations

Biological Activity for JTE 013

JTE 013 is a sphingosine-1-phosphate (S1P) receptor antagonist, highly selective for S1P₂ (EDG-5). Inhibits S1P binding to human S1P₂ receptors with an IC₅₀ value of 17.6 nM. At concentrations up to 10 μM, displays 4.2% inhibition of S1P₃ and does not antagonize S1P₁. Enhances S1P-induced angiogenesis in vivo.

Compound Libraries for JTE 013

JTE 013 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for JTE 013

M. Wt	408.29
Formula	C₁₇H₁₉N₇OCl₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	383150-41-2
PubChem ID	10223146
InChi Key	RNSLRQNDXRSASX-UHFFFAOYSA-N
Smiles	CC(C)C1=C2C(C)=NN(C)C2=NC(NNC(=O)NC2=CC(Cl)=NC(Cl)=C2)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for JTE 013

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	40.83	100
	ethanol	40.83	100

Preparing Stock Solutions for JTE 013

The following data is based on the product molecular weight 408.29.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.45 mL	12.25 mL	24.49 mL
5 mM	0.49 mL	2.45 mL	4.90 mL
10 mM	0.24 mL	1.22 mL	2.45 mL
50 mM	0.05 mL	0.24 mL	0.49 mL

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References for JTE 013

References are publications that support the biological activity of the product.

Parrill Sphingosine 1-phosphate and lysophosphatidic acid receptors: agonist and antagonist binding and progress toward development of receptor-specific ligands. Semin.Cell.Dev.Biol. 2004 PMID: 15271292
Inoki Negative regulation of endothelial morphogenesis and angiogenesis by S1P2 receptor. Biochem.Biophys.Res.Comm.
Ohmori Spingosine 1-phosphate induces contraction of coronary artery smooth muscle cells via S1P2. Cardiovasc.Res. 2003 PMID: 12667959