JTV 519 fumarate

Name: JTV 519 fumarate
Brand: Tocris Bioscience
SKU: 4564

Tocris Bioscience, part of Bio-Techne | Catalog # 4564

Citations (1)

COA / SDS

Ryanodine receptor (RyR) inhibitor

Key Product Details

Description:	Ryanodine receptor (RyR) inhibitor
Alternative Names:	K 201
Chemical Name:	1-(2,3-Dihydro-7-methoxy-1,4-benzothiazepin-4(5H)-yl)-3-[4-(phenylmethyl)-1-piperidinyl]-1-propanone fumarate
Purity:	≥98% (HPLC)
Molecular Weight:	540.67

View Full Technical Details for JTV 519 fumarate

Technical Data
Citations

Biological Activity for JTV 519 fumarate

JTV 519 fumarate is a ryanodine receptor (RyR) inhibitor; stabilizes RyR2 in a closed conformation. Exhibits antiarrhythmic and cardioprotective properties in vivo.

Technical Data for JTV 519 fumarate

M. Wt	540.67
Formula	C₂₅H₃₂N₂O₂S.C₄H₄O₄
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1883549-36-7
PubChem ID	91826075
InChi Key	ISLOBKLDZGDFTB-WLHGVMLRSA-N
Smiles	O=C(CCN3CCC(CC4=CC=CC=C4)CC3)N2CCSC1=CC=C(OC)C=C1C2.O=C(/C=C/C(O)=O)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for JTV 519 fumarate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	54.07	100

Preparing Stock Solutions for JTV 519 fumarate

The following data is based on the product molecular weight 540.67.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.85 mL	9.25 mL	18.50 mL
5 mM	0.37 mL	1.85 mL	3.70 mL
10 mM	0.18 mL	0.92 mL	1.85 mL
50 mM	0.04 mL	0.18 mL	0.37 mL

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References for JTV 519 fumarate

References are publications that support the biological activity of the product.

Chen Effect of K201, a novel antiarrhythmic drug on calcium handling and arrhythmogenic activity of pulmonary vein cardiomyocytes. Br.J.Pharmacol. 2008 PMID: 17994112
Ye Designing calcium release channel inhibitors with enhanced electron donor properties: stabilizing the closed state of ryanodine receptor type 1. Mol.Pharmacol. 2012 PMID: 21989257
Hunt K201 (JTV519) suppresses spontaneous Ca²⁺ release and [³H]ryanodine binding to RyR2 irrespective of FKBP12.6 association. Biochem.J. 2007 PMID: 17313373