JW 480

Name: JW 480
Brand: Tocris Bioscience
SKU: 4327

Tocris Bioscience, part of Bio-Techne | Catalog # 4327

COA / SDS

Potent and selective inhibitor of serine hydrolase KIAA1363 (AADACL1)

Key Product Details

Description:	Potent and selective inhibitor of serine hydrolase KIAA1363 (AADACL1)
Chemical Name:	2-Isopropylphenyl(2-(naphthalen-2-yl)ethyl)carbamate
Purity:	≥98% (HPLC)
Molecular Weight:	333.42

View Full Technical Details for JW 480

Technical Data
Citations

Biological Activity for JW 480

JW 480 is a potent and selective inhibitor of the serine hydrolase enzyme KIAA1363 (neutral cholesterol ester hydrolase 1 or NCEH1) (IC₅₀ = 20 nM in mouse brain). JW 480 impairs migration, invasion, survival and tumor growth of prostate cancer cell lines in vivo and reduces monoalkylglycerol ether (MAGE) levels.

Licensing Information

Sold under license from The Scripps Research Institute.

Technical Data for JW 480

M. Wt	333.42
Formula	C₂₂H₂₃NO₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1354359-53-7
PubChem ID	57330099
InChi Key	PCNJGBMWAZRVEA-UHFFFAOYSA-N
Smiles	CC(C)C1=CC=CC=C1OC(NCCC2=CC=C(C=CC=C3)C3=C2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for JW 480

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	33.34	100
	ethanol	33.34	100

Preparing Stock Solutions for JW 480

The following data is based on the product molecular weight 333.42.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.00 mL	15.00 mL	29.99 mL
5 mM	0.60 mL	3.00 mL	6.00 mL
10 mM	0.30 mL	1.50 mL	3.00 mL
50 mM	0.06 mL	0.30 mL	0.60 mL

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References for JW 480

References are publications that support the biological activity of the product.

Chang A potent and selective inhibitor of KIAA1363/AADACL1 that impairs prostate cancer pathogenesis. Chem.Biol. 2011 PMID: 21513884