JWH 133

Tocris Bioscience, part of Bio-Techne | Catalog # 1343

COA / SDS

Potent and selective CB2 agonist

Key Product Details

Description:	Potent and selective CB₂ agonist
Chemical Name:	(6aR,10aR)-3-(1,1-Dimethylbutyl)-6a,7,10,10a-tetrahydro-6,6,9-trimethyl-6H-dibenzo[b,d]pyran
Purity:	≥98% (HPLC)
Molecular Weight:	312.49

View Full Technical Details for JWH 133

Technical Data
Citations

Biological Activity for JWH 133

JWH 133 is a potent CB₂ selective agonist (K_i = 3.4 nM). Approx. 200-fold selective over CB₁ receptors. Active in vivo, reducing spasticity in a murine model of multiple sclerosis. Activity also enhances the release of IL-10 by LPS/IFN-γ-stimulated macrophages and results in downregulation of the IL-12 subunit p40.

Technical Data for JWH 133

M. Wt	312.49
Formula	C₂₂H₃₂O
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	259869-55-1
PubChem ID	6918505
InChi Key	YSBFLLZNALVODA-RBUKOAKNSA-N
Smiles	[H][C@]([C@]3([H])C(C)(C)O2)(CC(C)=CC3)C1=C2C=C(C(C)(C)CCC)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for JWH 133

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	31.25	100
	DMSO	6.25	20

Preparing Stock Solutions for JWH 133

The following data is based on the product molecular weight 312.49.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.20 mL	16.00 mL	32.00 mL
5 mM	0.64 mL	3.20 mL	6.40 mL
10 mM	0.32 mL	1.60 mL	3.20 mL
50 mM	0.06 mL	0.32 mL	0.64 mL

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References for JWH 133

References are publications that support the biological activity of the product.

Pertwee Pharmacology of cannabinoid receptor ligands. Curr.Med.Chem. 1999 PMID: 10469884
Correa Activation of cannabinoid CB₂ receptor negatively regulates IL-12p40 production in murine macrophages: role of IL-10 and ERK1/2 kinase signaling. Br.J.Pharmacol. 2005 PMID: 15821753
Huffman 3-(1'-Dimethylbutyl)-1-deoxy-Δ8-THC and related compounds: synthesis of selective ligands for the CB₂ receptor. Bioorg.Med.Chem. 1999 PMID: 10658595
Baker Cannabinoids control spasticity and tremor in a multiple sclerosis model. Nature 2000 PMID: 10716447