JX 06

Name: JX 06
Brand: Tocris Bioscience
SKU: 5845

Tocris Bioscience, part of Bio-Techne | Catalog # 5845

Citations (1)

COA / SDS

Potent and selective pyruvate dehydrogenase kinase (PDK) 1/2/3 inhibitor

Key Product Details

Description:	Potent and selective pyruvate dehydrogenase kinase (PDK) 1/2/3 inhibitor
Chemical Name:	Bis(morpholinothiocarbonyl) disulfide
Purity:	≥98% (HPLC)
Molecular Weight:	324.51

View Full Technical Details for JX 06

Technical Data
Citations

Biological Activity for JX 06

JX 06 is a potent and selective pyruvate dehydrogenase kinase (PDK) 1/2/3 inhibitor (IC₅₀ values are 49, 101 and 313 nM for PDK1, PDK2 and PDK3, respectively). Exhibits selectivity for PDK1/2/3 over PDK4 and a panel of 323 other kinases. Suppresses A549 lung cancer cell proliferation in vitro. Reduces tumor volume of A549 xenografts in mice.

Technical Data for JX 06

M. Wt	324.51
Formula	C₁₀H₁₆N₂O₂S₄
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	729-46-4
PubChem ID	12892
InChi Key	KKVYOWPPMNSLCP-UHFFFAOYSA-N
Smiles	S=C(SSC(N1CCOCC1)=S)N2CCOCC2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for JX 06

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	32.45	100

Preparing Stock Solutions for JX 06

The following data is based on the product molecular weight 324.51.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.08 mL	15.41 mL	30.82 mL
5 mM	0.62 mL	3.08 mL	6.16 mL
10 mM	0.31 mL	1.54 mL	3.08 mL
50 mM	0.06 mL	0.31 mL	0.62 mL

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References for JX 06

References are publications that support the biological activity of the product.

Sun JX06 selectively inhibits pyruvate dehydrogenase kinase PDK1 by a covalent cysteine modification. Cancer Res. 2015 PMID: 26483203