K 41498

Tocris Bioscience, part of Bio-Techne | Catalog # 2070

COA / SDS

Highly selective and potent CRF2 antagonist

Key Product Details

Description:	Highly selective and potent CRF₂ antagonist
Purity:	≥95% (HPLC)
Molecular Weight:	3632.26

View Full Technical Details for K 41498

Technical Data
Citations

Biological Activity for K 41498

K 41498 is a potent and highly selective CRF₂ receptor antagonist (K_i values are 0.66, 0.62 and 425 nM for human CRF_2α, CRF_2β and CRF₁ receptors respectively). Inhibits sauvagine-stimulated cAMP accumulation in hCRF_2α- and hCRF_2β-expressing cells. In rats in vivo, blocks urocortin-induced hypotension following systemic administration.

Licensing Information

Sold with the permission of the Max Planck Institute

Technical Data for K 41498

M. Wt	3632.26
Formula	C₁₆₂H₂₇₆N₄₈O₄₆
Single Letter Sequence	FHLLRKXIEIEKQEKEKQQAANNRLLLDTI (Modifications: Phe-1 = D-Phe, X = Nle, Ile-30 = C-terminal amide)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	434938-41-7
PubChem ID	90488734
InChi Key	QJWWADQIQXXJQA-DCUOZLBZSA-N
Smiles	[H]N[C@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)CC)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for K 41498

Solubility

Soluble to 5mg/ml in water

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for K 41498

References are publications that support the biological activity of the product.

Lawrence The highly selective CRF2 receptor antagonist K41498 binds to presynaptic CRF2 receptors in rat brain. Br.J.Pharmacol. 2002 PMID: 12110614
Ruhmann Design, synthesis and pharmacological characterization of new highly selective CRF2 antagonists: development of 123I-K31440 as a potential SPECT ligand. Peptides 2002 PMID: 11835994