Kaempferol

Name: Kaempferol
Brand: Tocris Bioscience
SKU: 3603

Tocris Bioscience, part of Bio-Techne | Catalog # 3603

(1)

Citations (10)

COA / SDS

Proapoptotic; downregulates PLK1 expression and activates mitochondrial Ca2+ uniporter

Key Product Details

Chemical Name:	3,5,7-Trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
Purity:	≥98%
Molecular Weight:	286.24 kDa

View Full Technical Details for Kaempferol

Technical Data
Citations / Reviews (1)

Biological Activity for Kaempferol

Activates the mitochondrial Ca²⁺ uniporter (EC₅₀ = 7 μM). Induces caspase-9-mediated apoptosis in cancer cell lines via downregulation of polo-like kinase 1 (PLK1) expression. Exhibits antioxidant activity and attenuates osteoclastic bone reabsorption in vitro. Also blocks EGF-induced histone H3Ser¹⁰ phosphorylation in mouse epidermal JB6 C141 cells. Activates transcriptional coactivator with PDZ-binding motif (TAZ) and increases osteoblast differentiation of mesenchymal stem cells while inhibiting adipocyte differentiation. Naturally occurring flavonoid found in Gingko biloba and red wine. Kaempferol has antiviral activity against Japanese encephalitis virus (JEV) in infected BHK21 (EC₅₀ = 21.5 μM). Kaempferol directly inhibits viral replication and protein expression by binding JEV frameshift site RNA (fsRNA). Kaempferol influences frameshift efficiency in virus-infected cells through interfering with a downstream RNA pseudoknot structure. Kaempferol has also been reported to exhibit activity against herpes simplex virus, influenza viruses (H1N1 and H9N2) and hepatitis B virus under in vitro conditions.

Technical Data for Kaempferol

M. Wt	286.24 kDa
Formula	C₁₅H₁₀O₆
Storage	Store at +4°C
Purity	≥98%
CAS Number	520-18-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Kaempferol

Solubility

Soluble Soluble to 100 mM in DMSO and to 100 mM in ethanol

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References for Kaempferol

References are publications that support the biological activity of the product.

Hao Y, Kuang Z, Jing J, Miao J, Mei L, Lee R, Kim S, Choe S, Krause D, Lau G Mycoplasma pneumoniae modulates STAT3-STAT6/EGFR-FOXA2 signaling to induce overexpression of airway mucins. Infect Immun, 2014;82(12):5246-55. 2014 PMID: 25287927
Cho et al. Ribosomal S6 kinase 2 is a key regulator in tumor promoter induced cell transformation. Cancer Res., 2007;67:8104 PMID: 17804722
Montero et al. Direct activation of the mitochondrial calcium uniporter by natural plant flavonoids. Biochem.J., 2004;384:19 PMID: 15324303
Suh et al. Kaempferol attenuates 2-deoxy-D-ribose-induced oxidative cell damage in MC3T3-E1 osteoblastic cells. Biol.Pharm.Bull., 2009;32:746 PMID: 19336918
Kang et al. Downregulation of PLK-1 expression in kaempferol-induced apoptosis of MCF-7 cells. Eur.J.Pharmacol., 2009;611:17 PMID: 19356725
Vay et al. Modulation of Ca²⁺ release and Ca²⁺ oscillations in HeLa cells and fibroblasts by mitochondrial Ca²⁺ uniporter stimulation. J.Physiol., 2009;580:39
Byun et al. TAZ is required for the osteogenic and anti-adipogenic activities of kaempferol. Bone, 2012;50:364 PMID: 22108137