kb NB 142-70

Name: kb NB 142-70
Brand: Tocris Bioscience
SKU: 3962

Tocris Bioscience, part of Bio-Techne | Catalog # 3962

Citations (9)

COA / SDS

Selective PKD inhibitor; analog of CID 755673 (Cat. No. 3327)

Key Product Details

Description:	Selective PKD inhibitor; analog of CID 755673 (Cat. No. 3327)
Chemical Name:	9-Hydroxy-3,4-dihydro-2H-[1]-benzothiolo[2,3-f][1,4]thiazepin-5-one
Purity:	≥98% (HPLC)
Molecular Weight:	251.32

View Full Technical Details for kb NB 142-70

Technical Data
Citations

Biological Activity for kb NB 142-70

kb NB 142-70 is a selective protein kinase D (PKD) inhibitor (IC₅₀ values are 28.3, 58.7 and 53.2 nM for PKD1, 2 and 3 respectively). More potent analog of CID 755673 (Cat. No. 3327) with 7-fold greater inhibition. Inhibits prostrate cancer cell migration and invasion and reduces wound healing in vitro; displays prominent cytotoxic and anti-proliferative effects.

Technical Data for kb NB 142-70

M. Wt	251.32
Formula	C₁₁H₉NO₂S₂
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	1233533-04-4
PubChem ID	45258277
InChi Key	DHUAGGSHTKPOHU-UHFFFAOYSA-N
Smiles	OC1=CC=C(SC3=C2SCCNC3=O)C2=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for kb NB 142-70

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	25.13	100

Preparing Stock Solutions for kb NB 142-70

The following data is based on the product molecular weight 251.32.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.98 mL	19.89 mL	39.79 mL
5 mM	0.80 mL	3.98 mL	7.96 mL
10 mM	0.40 mL	1.99 mL	3.98 mL
50 mM	0.08 mL	0.40 mL	0.80 mL

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References for kb NB 142-70

References are publications that support the biological activity of the product.

Bravo-Altamirano Synthesis and structure-activity relationships of benzothienothiazepinone inhibitors of protein kinase D. ACS Med.Chem.Lett. 2011 PMID: 21617763
Ni PKD1 mediates negative feedback of PI3K/Akt activation in response to G protein-coupled receptors. PLoS One 2013 PMID: 24039875
LaValle Novel protein kinase D inhibitors cause potent arrest in cancer cell growth and motility. BMC Chemical Biology 2010 PMID: 20444281