KHS 101 hydrochloride

Name: KHS 101 hydrochloride
Brand: Tocris Bioscience
SKU: 4888

Tocris Bioscience, part of Bio-Techne | Catalog # 4888

Citations (2)

COA / SDS

Selective inducer of neuronal differentiation in hippocampal neural progenitors

Key Product Details

Description:	Selective inducer of neuronal differentiation in hippocampal neural progenitors
Chemical Name:	N4-(2-Methylpropyl)-N²-[(2-phenyl-4-thiazolyl)methyl]-2,4-pyrimidinediamine hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	375.92

View Full Technical Details for KHS 101 hydrochloride

Technical Data
Citations

Biological Activity for KHS 101 hydrochloride

KHS 101 hydrochloride is a selective inducer of neuronal differentiation; induces neuronal differentiation in cultured hippocampal neural progenitor cells (NPCs) by interacting with TACC3 (EC₅₀ ~1 μM). Suppresses astrocyte formation. Also induces acceleration of neuronal differentiation in the hippocampal dentate gyrus in vivo.

Compound Libraries for KHS 101 hydrochloride

KHS 101 hydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for KHS 101 hydrochloride

M. Wt	375.92
Formula	C₁₈H₂₁N₅S.HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	1784282-12-7
PubChem ID	90488983
InChi Key	INVQHPQJFRKGIO-UHFFFAOYSA-N
Smiles	CC(C)CNC1=NC(NCC2=CSC(C3=CC=CC=C3)=N2)=NC=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for KHS 101 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	18.8	50
	ethanol	18.8	50

Preparing Stock Solutions for KHS 101 hydrochloride

The following data is based on the product molecular weight 375.92.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.32 mL	26.60 mL	53.20 mL
2.5 mM	1.06 mL	5.32 mL	10.64 mL
5 mM	0.53 mL	2.66 mL	5.32 mL
25 mM	0.11 mL	0.53 mL	1.06 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for KHS 101 hydrochloride

References are publications that support the biological activity of the product.

Wurdak A small molecule accelerates neuronal differentiation in the adult rat. Proc.Natl.Acad.Sci.USA. 2010 PMID: 20823227