KI-7

Name: KI-7
Brand: Tocris Bioscience
SKU: 6787

Tocris Bioscience, part of Bio-Techne | Catalog # 6787

COA / SDS

Positive allosteric modulator of A2B receptors

Key Product Details

Description:	Positive allosteric modulator of A_2B receptors
Chemical Name:	α-Oxo-N-phenyl-1-(phenylmethyl)-1H-indole-3-acetamide
Purity:	≥98% (HPLC)
Molecular Weight:	354.4

View Full Technical Details for KI-7

Technical Data
Citations

Biological Activity for KI-7

KI-7 is an adenosine A_2B receptor positive allosteric modulator. Potentiates the NECA (Cat. No. 1691) -induced increase in cAMP production in CHO cells expressing A_2B receptors. Also potentiates the effects of NECA and the A_2B receptor agonist BAY 60-6583 (Cat. No. 4472) in mediating osteoblast differentiation from MSCs in vitro.

Compound Libraries for KI-7

KI-7 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for KI-7

M. Wt	354.4
Formula	C₂₃H₁₈N₂O₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1489263-00-4
PubChem ID	73350966
InChi Key	MQMGZFRIEZRHHJ-UHFFFAOYSA-N
Smiles	O=C(C(C1=CN(C2=CC=CC=C12)CC3=CC=CC=C3)=O)NC4=CC=CC=C4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for KI-7

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	17.72	50

Preparing Stock Solutions for KI-7

The following data is based on the product molecular weight 354.4.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.64 mL	28.22 mL	56.43 mL
2.5 mM	1.13 mL	5.64 mL	11.29 mL
5 mM	0.56 mL	2.82 mL	5.64 mL
25 mM	0.11 mL	0.56 mL	1.13 mL

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References for KI-7

References are publications that support the biological activity of the product.

Trincavelli Allosteric modulators of human A_2B adenosine receptor. Biochim.Biophys.Acta 2014 PMID: 24361612
Trincavelli Osteoblast differentiation and survival: A role for A_2B adenosine receptor allosteric modulators. Biochim.Biophys.Acta 2014 PMID: 25241343