KN 93 phosphate

Biological Activity for KN 93 phosphate

Technical Data for KN 93 phosphate

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for KN 93 phosphate

References for KN 93 phosphate

References are publications that support the biological activity of the product.

• A Tsakmaki, P Fonseca Pe, P Pavlidis, B Hayee, GA Bewick ISX-9 manipulates endocrine progenitor fate revealing conserved intestinal lineages in mouse and human organoids Mol Metab, 2020;34(0):157-173. 2020 PMID: 32180555
• J Mitlöhner, R Kaushik, H Niekisch, A Blondiaux, CE Gee, MFK Happel, E Gundelfing, A Dityatev, R Frischknec, C Seidenbech Dopamine Receptor Activation Modulates the Integrity of the Perisynaptic Extracellular Matrix at Excitatory Synapses Cells, 2020;9(2):. 2020 PMID: 31972963
• Anderson et al. KN-93, an inhibitor of multifunctional Ca²⁺/calmodulin-dependent protein kinase, decreases early afterdepolarizations in rabbit heart. J.Pharmacol.Exp.Ther., 1998;287:996 PMID: 9864285
• Sumi et al. The newly synthesized selective Ca²⁺/calmodulin dependent protein kinase II inhibitor KN-93 reduces DA content in PC12h cells. Biochem.Biophys.Res.Comm., 1991;181:968 PMID: 1662507
• Bruno et al. Microwave-assisted synthesis of KN-93, a potent and selective inhibitor or Ca²⁺/Calmoduline-dependent protein kinase II. Synthesis, 2010;24:4193
• Rezazadeh et al. KN-93 (2-[N-(2-Hydroxyethyl)]-N-(4-methoxybenzenesulfonyl)]-amino-N-(4-chlorocinnamyl)-N-methylbenzylamine), a calcium/calmodulin-dependent protein kinase II inhibitor, is a direct extracellular blocker of voltage-gated J.Pharmacol.Exp.Ther., 2006;317:292 PMID: 16368898