KN 93 phosphate

Name: KN 93 phosphate
Brand: Tocris Bioscience
SKU: 5215
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 5215

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Citations (7)

COA / SDS

CaM kinase II inhibitor; water soluble version of KN 93 (Cat. No. 1278)

Key Product Details

Description:	CaM kinase II inhibitor; water soluble version of KN 93 (Cat. No. 1278)
Chemical Name:	N-[2-[[[3-(4-Chlorophenyl)-2-propenyl]methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4-methoxybenzenesulphonamide phosphate
Purity:	≥98% (HPLC)
Molecular Weight:	599.03

View Full Technical Details for KN 93 phosphate

Technical Data
Citations / Reviews (1)

Biological Activity for KN 93 phosphate

KN 93 phosphate is a CaM kinase II inhibitor; water soluble version of KN 93 (Cat. No. 1278).

Technical Data for KN 93 phosphate

M. Wt	599.03
Formula	C₂₆H₂₉ClN₂O₄S.H₃PO₄
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1188890-41-6
PubChem ID	16760530
InChi Key	NNKJTPOXLIILMB-IPZCTEOASA-N
Smiles	O=S(N(CCO)C1=C(CN(C)C/C=C/C3=CC=C(Cl)C=C3)C=CC=C1)(C2=CC=C(OC)C=C2)=O.O=P(O)(O)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for KN 93 phosphate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	5.99	10

Preparing Stock Solutions for KN 93 phosphate

The following data is based on the product molecular weight 599.03.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	16.69 mL	83.47 mL	166.94 mL
0.5 mM	3.34 mL	16.69 mL	33.39 mL
1 mM	1.67 mL	8.35 mL	16.69 mL
5 mM	0.33 mL	1.67 mL	3.34 mL

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Reconstitution Calculator

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References for KN 93 phosphate

References are publications that support the biological activity of the product.

Bruno Microwave-assisted synthesis of KN-93, a potent and selective inhibitor or Ca²⁺/Calmoduline-dependent protein kinase II. Synthesis
Sumi The newly synthesized selective Ca²⁺/calmodulin dependent protein kinase II inhibitor KN-93 reduces DA content in PC12h cells. Biochem.Biophys.Res.Comm. 1991 PMID: 1662507
Rezazadeh KN-93 (2-[N-(2-Hydroxyethyl)]-N-(4-methoxybenzenesulfonyl)]-amino-N-(4-chlorocinnamyl)-N-methylbenzylamine), a calcium/calmodulin-dependent protein kinase II inhibitor, is a direct extracellular blocker of voltage-gated J.Pharmacol.Exp.Ther. 2006 PMID: 16368898
Anderson KN-93, an inhibitor of multifunctional Ca²⁺/calmodulin-dependent protein kinase, decreases early afterdepolarizations in rabbit heart. J.Pharmacol.Exp.Ther. 1998 PMID: 9864285