KT 5823

Name: KT 5823
Brand: Tocris Bioscience
SKU: 1289

Tocris Bioscience, part of Bio-Techne | Catalog # 1289

Citations (58)

COA / SDS

Selective protein kinase G inhibitor

Key Product Details

Description:	Selective protein kinase G inhibitor
Chemical Name:	(9S,10R,12R)-2,3,9,10,11,12-Hexahydro-10-methoxy-2,9-dimethyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, methyl ester
Purity:	≥95% (HPLC)
Molecular Weight:	495.53

View Full Technical Details for KT 5823

Technical Data
Citations

Biological Activity for KT 5823

KT 5823 is a selective inhibitor of protein kinase G (K_i values are 0.23, 4 and > 10 μM for inhibition of PKG, PKC and PKA respectively). Inhibits SNP-stimulated PKG activity with an IC₅₀ of 60 nM in dispersed smooth muscle cells and has little effect on PKA activity at concentrations of up to 10 μM.

Technical Data for KT 5823

M. Wt	495.53
Formula	C₂₉H₂₅N₃O₅
Storage	Desiccate at -20°C
Purity	≥95% (HPLC)
CAS Number	126643-37-6
PubChem ID	108152
InChi Key	QTYMDECKVKSGSM-YMUMJAELSA-N
Smiles	[H][C@]18O[C@](N6C4=C3N1C2=CC=CC=C2C3=C7C(CN(C7=O)C)=C4C5=CC=CC=C56)([C@]([C@@](OC)=O)(OC)C8)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for KT 5823

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	24.78	50

Preparing Stock Solutions for KT 5823

The following data is based on the product molecular weight 495.53.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.04 mL	20.18 mL	40.36 mL
2.5 mM	0.81 mL	4.04 mL	8.07 mL
5 mM	0.40 mL	2.02 mL	4.04 mL
25 mM	0.08 mL	0.40 mL	0.81 mL

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References for KT 5823

References are publications that support the biological activity of the product.

Murthy and Makhlouf Interaction of cA-kinase and cG-kinase in mediating relaxation of dispersed smooth muscle cells. Am.J.Physiol. 1995 PMID: 7840145
Smolenski Functional analysis of cGMP-dependent protein kinases I and II as mediators of NO/cGMP effects. Naunyn Schmiedebergs Arch.Pharmacol. 1998 PMID: 9721015
Gadbois Multiple kinase arrest points in the G₁ phase of nontransformed mammalian cells are absent in transformed cells. Proc.Natl.Acad.Sci.U.S.A. 1992 PMID: 1528872