KU 55933

Name: KU 55933
Brand: Tocris Bioscience
SKU: 3544
Rating: 5 (2 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 3544

(2)

Citations (265)

COA / SDS

Potent and selective ATM kinase inhibitor

Key Product Details

Description:	Potent and selective ATM kinase inhibitor
Chemical Name:	2-(4-Morpholinyl)-6-(1-thianthrenyl)-4H-pyran-4-one
Purity:	≥98% (HPLC)
Molecular Weight:	395.49

View Full Technical Details for KU 55933

Technical Data
Citations / Reviews (2)

Biological Activity for KU 55933

KU 55933 is a potent, selective and competitive ATM kinase inhibitor (K_i = 2.2 nM, IC₅₀ values are 13, 2500, 9300, 16600, > 100000 and > 100000 nM at ATM, DNA-PK, mTOR, PI 3-kinase, PI 4-K and ATR respectively). Decreases viability of MCF-7, A549 and HCT116 cells and decreases p21^CIP1 levels in vitro. Acts as a radio- and chemosensitizer for the treatment of cancer.

Technical Data for KU 55933

M. Wt	395.49
Formula	C₂₁H₁₇NO₃S₂
Storage	Desiccate at -20°C
Purity	≥98% (HPLC)
CAS Number	587871-26-9
PubChem ID	5278396
InChi Key	XRKYMMUGXMWDAO-UHFFFAOYSA-N
Smiles	O=C1C=C(C3=CC=CC4=C3SC5=C(C=CC=C5)S4)OC(N2CCOCC2)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for KU 55933

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	39.55	100
	ethanol	19.77	50

Preparing Stock Solutions for KU 55933

The following data is based on the product molecular weight 395.49.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.53 mL	12.64 mL	25.29 mL
5 mM	0.51 mL	2.53 mL	5.06 mL
10 mM	0.25 mL	1.26 mL	2.53 mL
50 mM	0.05 mL	0.25 mL	0.51 mL

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References for KU 55933

References are publications that support the biological activity of the product.

Eaton Ataxia-telangiectasia mutated kinase regulates ribonucleotide reductase and mitochondrial homeostasis. J.Clin.Invest. 2007 PMID: 17786248
Crescenzi Ataxia telangiectasia mutated and p21CIP1 modulate cell survival of drug-induced senescent tumor cells: implications for chemotherapy. Clin.Cancer Res. 2008 PMID: 18347191
Hickson Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM. Cancer Res. 2004 PMID: 15604286