KU 55933

Biological Activity for KU 55933

Technical Data for KU 55933

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for KU 55933

References for KU 55933

References are publications that support the biological activity of the product.

• Ekta Tripathi Cell cycle-regulated ubiquitination of tankyrase 1 by RNF8 and ABRO1/BRCC36 controls the timing of sister telomere resolution EMBO J, 2016;0(0):. 2016 PMID: 27993934
• S Moore, ND Berger, MS Luijsterbu, CG Piett, FKT Stanley, CU Schräder, S Fang, JA Chan, DC Schriemer, ZD Nagel, H van Attiku, AA Goodarzi The CHD6 chromatin remodeler is an oxidative DNA damage response factor Nat Commun, 2019;10(1):241. 2019 PMID: 30651562
• Henriksson S, Rassoolzadeh H, Hedstrom E, Coucoravas C, Julner A, Goldstein M, Imreh G, Zhivotovsky B, Kastan M, Helleday T, Farnebo M The scaffold protein WRAP53beta orchestrates the ubiquitin response critical for DNA double-strand break repair. Genes Dev, 2014;28(24):2726-38. 2014 PMID: 25512560
• S Wang, AM Pike, SS Lee, MA Strong, CJ Connelly, CW Greider BRD4 inhibitors block telomere elongation Nucleic Acids Res., 2017;45(14):8403-8410. 2017 PMID: 28854735
• Weyemi, Urbain, Redon, Christop, Aziz, Towqir, Choudhuri, Rohini, Maeda, Daisuke, Parekh, Palak R, Bonner, Michael, Arbiser, Jack L, Bonner, William NADPH oxidase 4 is a critical mediator in Ataxia telangiectasia disease. Proc Natl Acad Sci U S A, 2015;112(7):2121-6. 2015 PMID: 25646414
• Q Wu, A Allouch, A Paoletti, C Leteur, C Mirjolet, I Martins, L Voisin, F Law, H Dakhli, E Mintet, M Thoreau, Z Muradova, M Gauthier, O Caron, F Milliat, DM Ojcius, F Rosselli, E Solary, N Modjtahedi, E Deutsch, JL Perfettini NOX2-dependent ATM kinase activation dictates pro-inflammatory macrophage phenotype and improves effectiveness to radiation therapy Cell Death Differ., 2017;0(0):. 2017 PMID: 28574504
• Shi Y, Nikulenkov F, Zawacka-Pankau J, Li H, Gabdoulline R, Xu J, Eriksson S, Hedstrom E, Issaeva N, Kel A, Arner E, Selivanova G ROS-dependent activation of JNK converts p53 into an efficient inhibitor of oncogenes leading to robust apoptosis. Cell Death Differ, 2014;21(4):612-23. 2014 PMID: 24413150
• Fumagalli M, Rossiello F, Clerici M Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation. Nat. Cell Biol., 2012;14(4):355-65. 2012 PMID: 22426077
• Leung W, Vong Q, Lin W, Janke L, Chen T, Leung W Modulation of NKG2D ligand expression and metastasis in tumors by spironolactone via RXRgamma activation. J Exp Med, 2013;210(12):2675-92. 2013 PMID: 24190430
• Yuan J, Luo K, Liu T Regulation of SIRT1 activity by genotoxic stress. Genes Dev., 2012;26(8):791-6. 2012 PMID: 22465953
• Hickson I, Zhao Y, Richardson CJ et al. Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM. Cancer Res 2004-12-01 PMID: 15604286
• Crescenzi et al. Ataxia telangiectasia mutated and p21CIP1 modulate cell survival of drug-induced senescent tumor cells: Implications for chemotherapy. Clin.Cancer Res., 2008;14:1877 PMID: 18347191
• Eaton et al. Ataxia-telangiectasia mutated kinase regulates ribonucleotide reductase and mitochondrial homeostasis. J.Clin.Invest., 2007;117:2723 PMID: 17786248