KY 02111

Name: KY 02111
Brand: Tocris Bioscience
SKU: 4731

Tocris Bioscience, part of Bio-Techne | Catalog # 4731

Citations (9)

COA / SDS

Inhibits canonical Wnt signaling. Promotes differentiation of human ESCs and iPSCs into cardiomyocytes

Key Product Details

Chemical Name:	N-(6-Chloro-2-benzothiazolyl)-3,4-dimethoxybenzenepropanamide
Purity:	≥98%

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Technical Data
Citations

Biological Activity for KY 02111

KY 02111 promotes differentiation of human ESCs and iPSCs into cardiomyocytes when used after day three in culture; differentiation efficiency increases when used after initial culture with CHIR 99021 (Cat. No. 4423). Induces downregulation of Wnt signaling target genes; inhibits canonical Wnt signaling in a manner distinct from other known Wnt inhibitors.

Technical Data for KY 02111

Formula	C₁₈H₁₇ClN₂O₃S
Storage	Store at +4°C
Purity	≥98%
CAS Number	1118807-13-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for KY 02111

Solubility

Soluble Soluble to 50 mM in DMSO

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References for KY 02111

References are publications that support the biological activity of the product.

JGW Smith, T Owen, JR Bhagwan, D Mosqueira, E Scott, I Mannhardt, A Patel, R Barriales-, L Monserrat, A Hansen, T Eschenhage, SE Harding, S Marston, C Denning Isogenic Pairs of hiPSC-CMs with Hypertrophic Cardiomyopathy/LVNC-Associated ACTC1 E99K Mutation Unveil Differential Functional Deficits Stem Cell Reports, 2018;0(0):. 2018 PMID: 30392975
Minami et al. A small molecule that promotes cardiac differentiation of human pluripotent stem cells under defined, cytokine- and xeno-free conditions. Cell Rep., 2012;2:1448 PMID: 23103164

KY 02111

Tocris Bioscience, part of Bio-Techne | Catalog # 4731

Key Product Details

Biological Activity for KY 02111

Technical Data for KY 02111

Solubility for KY 02111

Dilution Calculator

Reconstitution Calculator

References for KY 02111

Product Documents for KY 02111

COA

Certificate of Analysis

SDS

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