KY 02111

Name: KY 02111
Brand: Tocris Bioscience
SKU: 4731

Tocris Bioscience, part of Bio-Techne | Catalog # 4731

Citations (9)

COA / SDS

Inhibits canonical Wnt signaling. Promotes differentiation of human ESCs and iPSCs into cardiomyocytes

Key Product Details

Description:	Inhibits canonical Wnt signaling. Promotes differentiation of human ESCs and iPSCs into cardiomyocytes
Chemical Name:	N-(6-Chloro-2-benzothiazolyl)-3,4-dimethoxybenzenepropanamide
Purity:	≥98% (HPLC)
Molecular Weight:	376.86

View Full Technical Details for KY 02111

Technical Data
Citations

Biological Activity for KY 02111

KY 02111 promotes differentiation of human ESCs and iPSCs into cardiomyocytes when used after day three in culture; differentiation efficiency increases when used after initial culture with CHIR 99021 (Cat. No. 4423). Induces downregulation of Wnt signaling target genes; inhibits canonical Wnt signaling in a manner distinct from other known Wnt inhibitors.

Compound Libraries for KY 02111

KY 02111 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for KY 02111

M. Wt	376.86
Formula	C₁₈H₁₇ClN₂O₃S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1118807-13-8
PubChem ID	8582409
InChi Key	LXFKEVQQSKQXPR-UHFFFAOYSA-N
Smiles	O=C(CCC3=CC=C(OC)C(OC)=C3)NC2=NC1=CC=C(Cl)C=C1S2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for KY 02111

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	18.84	50

Preparing Stock Solutions for KY 02111

The following data is based on the product molecular weight 376.86.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.31 mL	26.54 mL	53.07 mL
2.5 mM	1.06 mL	5.31 mL	10.61 mL
5 mM	0.53 mL	2.65 mL	5.31 mL
25 mM	0.11 mL	0.53 mL	1.06 mL

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References for KY 02111

References are publications that support the biological activity of the product.

Minami A small molecule that promotes cardiac differentiation of human pluripotent stem cells under defined, cytokine- and xeno-free conditions. Cell Rep. 2012 PMID: 23103164