L-152,804

Name: L-152,804
Brand: Tocris Bioscience
SKU: 1382

Tocris Bioscience, part of Bio-Techne | Catalog # 1382

Citations (26)

COA / SDS

Potent, selective non-peptide NPY Y5 receptor antagonist

Key Product Details

Description:	Potent, selective non-peptide NPY Y₅ receptor antagonist
Chemical Name:	5,5-Dimethyl-2-(2,3,4,9-tetrahydro-3,3-dimethyl-1oxo-1H-xanthen-9-yl)-1,3-cyclohexanedione
Purity:	≥99% (HPLC)
Molecular Weight:	366.46

View Full Technical Details for L-152,804

Technical Data
Citations

Biological Activity for L-152,804

L-152,804 is a potent, selective non-peptide neuropeptide Y Y₅ receptor antagonist (K_i = 26 nM for hY₅). Displays > 300-fold selectivity over hY₁, hY₂, and hY₄ receptors. Causes weight loss in diet-induced obese mice by modulating food intake and energy expenditure. Centrally active upon oral administration in vivo.

Technical Data for L-152,804

M. Wt	366.46
Formula	C₂₃H₂₆O₄
Storage	Desiccate at +4°C
Purity	≥99% (HPLC)
CAS Number	6508-43-6
PubChem ID	3765615
InChi Key	XQDXIHYKAGHZRX-UHFFFAOYSA-N
Smiles	CC1(C)CC(=O)C(C2C3=C(OC4=C2C(=O)CC(C)(C)C4)C=CC=C3)C(=O)C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for L-152,804

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	36.65	100

Preparing Stock Solutions for L-152,804

The following data is based on the product molecular weight 366.46.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.73 mL	13.64 mL	27.29 mL
5 mM	0.55 mL	2.73 mL	5.46 mL
10 mM	0.27 mL	1.36 mL	2.73 mL
50 mM	0.05 mL	0.27 mL	0.55 mL

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References for L-152,804

References are publications that support the biological activity of the product.

Mashiko A pair-feeding study reveals that a Y₅ antagonist causes weight loss in diet-induced obese mice by modulating food intake and energy expenditure. Mol.Pharmacol. 2007 PMID: 17105869
Schroeder The neuropeptide-Y Y5 receptor antagonist L-152,804 decreases alcohol self-administration in inbred alcohol-preferring (iP) rats. Alcohol 2005 PMID: 16377459
Kanatani L-152,804: orally active and selective neuropeptide Y Y₅ receptor antagonist. Biochem.Biophys.Res.Commun. 2000 PMID: 10872822