L-651,582

Name: L-651,582
Brand: Tocris Bioscience
SKU: 3086

Tocris Bioscience, part of Bio-Techne | Catalog # 3086

COA / SDS

Non-selective Ca2+ channel blocker

Key Product Details

Description:	Non-selective Ca²⁺ channel blocker
Alternative Names:	Carboxyamidotriazole
Chemical Name:	5-Amino-1-[[3,5-dichloro-4-(4-chlorobenzoyl)phenyl]methyl]-1H-1,2,3-triazole-4-carboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	424.67

View Full Technical Details for L-651,582

Technical Data
Citations

Biological Activity for L-651,582

L-651,582 is an orally active Ca²⁺ channel blocker; inhibits K⁺- and carbachol-stimulated Ca²⁺ influx (IC₅₀ values are 500 and 935 nM respectively). Exhibits antiproliferative, antiangiogenic and antimetastatic activity in vivo and displays selectivity towards numerous mismatch repair-deficient tumor cell lines in vitro.

Technical Data for L-651,582

M. Wt	424.67
Formula	C₁₇H₁₂Cl₃N₅O₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	99519-84-3
PubChem ID	108144
InChi Key	WNRZHQBJSXRYJK-UHFFFAOYSA-N
Smiles	ClC1=CC=C(C(C2=C(Cl)C=C(CN3N=NC(C(N)=O)=C3N)C=C2Cl)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for L-651,582

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	42.47	100

Preparing Stock Solutions for L-651,582

The following data is based on the product molecular weight 424.67.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.35 mL	11.77 mL	23.55 mL
5 mM	0.47 mL	2.35 mL	4.71 mL
10 mM	0.24 mL	1.18 mL	2.35 mL
50 mM	0.05 mL	0.24 mL	0.47 mL

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References for L-651,582

References are publications that support the biological activity of the product.

Yang Selective sensitivity to carboxyamidotriazole by human tumor cell lines with DNA mismatch repair deficiency. Int.J.Cancer. 2008 PMID: 18464258
Felder The antiproliferative and antimetastatic compound L651582 inhibits muscarinic acetylcholine receptor-stimulated calcium influx and arachidonic acid release. J.Pharm.Exp.Ther.
Hupe The inhibition of receptor-mediated and voltage-dependent calcium entry by the antiproliferative L-651,582 J.Biol.Chem. 1991 PMID: 1645340