L-741,626

Name: L-741,626
Brand: Tocris Bioscience
SKU: 1003

Tocris Bioscience, part of Bio-Techne | Catalog # 1003

Citations (71)

COA / SDS

High affinity D2 antagonist

Key Product Details

Description:	High affinity D₂ antagonist
Chemical Name:	3-[[4-(4-Chlorophenyl)-4-hydroxypiperidin-l-yl]methyl-1H-indole
Purity:	≥98% (HPLC)
Molecular Weight:	340.85

View Full Technical Details for L-741,626

Technical Data
Citations

Biological Activity for L-741,626

L-741,626 is a potent D₂ dopamine receptor selective antagonist, with affinities of 2.4, 100 and 220 nM for D₂, D₃ and D₄ receptors respectively. Centrally active following systemic administration in vivo.

Licensing Information

Sold with the permission of Merck Sharp and Dohme Ltd.

Compound Libraries for L-741,626

L-741,626 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for L-741,626

M. Wt	340.85
Formula	C₂₀H₂₁ClN₂O
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	81226-60-0
PubChem ID	133633
InChi Key	LLBLNMUONVVVPG-UHFFFAOYSA-N
Smiles	OC1(CCN(CC2=CNC3=CC=CC=C23)CC1)C1=CC=C(Cl)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for L-741,626

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	34.09	100
	ethanol	34.09	100

Preparing Stock Solutions for L-741,626

The following data is based on the product molecular weight 340.85.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.93 mL	14.67 mL	29.34 mL
5 mM	0.59 mL	2.93 mL	5.87 mL
10 mM	0.29 mL	1.47 mL	2.93 mL
50 mM	0.06 mL	0.29 mL	0.59 mL

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References for L-741,626

References are publications that support the biological activity of the product.

Pillai Human D2 and D4 DA receptors couple through βγ G-protein subunits to inwardly rectifying K+ channels (GIRK1) in a Xenopus oocyte expression system: selective antagonism by L-741,626 and L-745,870 respect Neuropharmacology 1998 PMID: 9833627
Kulagowski 3-[[4-(4-Chlorophenyl)piperazin-1-yl]methyl]-1H-pyrrolo[2,3-b]pyridine: an antagonist with high affinity and selectivity for the human DA D₄ receptor. J.Med.Chem. 1996 PMID: 8642550
Millan S33084, a novel, potent, selective, and competitive antagonist at DA D₃-receptors: II. Functional and behavioral profile compared with GR218,231 and L741,626. J.Pharmacol.Exp.Ther. 2000 PMID: 10869411
Bowery Antagonism of the effects of (+)-PD 128907 on midbrain DA neurones in rat brain slices by a selective D₂ receptor antagonist L-741,626. Br.J.Pharmacol. 1996 PMID: 8968560