L 760735

Name: L 760735
Brand: Tocris Bioscience
SKU: 4013

Tocris Bioscience, part of Bio-Techne | Catalog # 4013

Citations (6)

COA / SDS

High affinity NK1 antagonist

Key Product Details

Chemical Name:	5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl-N,N-dimethyl-1H-1,2,3-triazole-4-methanamine hydrochloride
Purity:	≥99%
Molecular Weight:	611.98 kDa

View Full Technical Details for L 760735

Technical Data
Citations

Biological Activity for L 760735

L 760735 is a high affinity NK₁ receptor antagonist (IC₅₀ = 0.19 nM at human NK₁ receptors). Selective (>300-fold) over h-NK₂ and h-NK₃ receptors. Exhibits anxiolytic and antidepressant-like effects. Orally active.

Technical Data for L 760735

M. Wt	611.98 kDa
Formula	C₂₆H₂₈F₇N₅O₂.HCl
Storage	Store at -20°C
Purity	≥99%
CAS Number	188923-01-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for L 760735

Solubility

Soluble Soluble to 30 mM in water and to 50 mM in DMSO

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for L 760735

References are publications that support the biological activity of the product.

SM Johnson, KS Randhawa, TL Baker, JJ Watters Respiratory frequency plasticity during development Respir Physiol Neurobiol, 2019;0(0):. 2019 PMID: 31055188
Duffy et al. Correlation of neurokinin (NK) 1 receptor occupancy in gerbil striatum with behavioral effects of NK1 antagonists. J.Pharmacol.Exp.Ther., 2002;301:536 PMID: 11961054
Harrison et al. An orally active, water-soluble neurokinin-1 receptor antagonist suitable for both intravenous and oral clinical administration. J.Med.Chem., 2001;44:4296 PMID: 11708932