L-Buthionine sulfoximine

Name: L-Buthionine sulfoximine
Brand: Tocris Bioscience
SKU: 6954

Tocris Bioscience, part of Bio-Techne | Catalog # 6954

Citations (3)

COA / SDS

Irreversible γ-glutamylcysteine synthetase (γ-GCS) inhibitor; induces ferroptosis

Key Product Details

Description:	Irreversible γ-glutamylcysteine synthetase (γ-GCS) inhibitor; induces ferroptosis
Chemical Name:	(2S)-2-Amino-4-(S-butylsulfonimidoyl)butanoic acid
Purity:	≥98% (HPLC)
Molecular Weight:	222.3

View Full Technical Details for L-Buthionine sulfoximine

Technical Data
Citations

Biological Activity for L-Buthionine sulfoximine

L-Buthionine sulfoximine is an irreversible γ-glutamylcysteine synthetase (γ-GCS) inhibitor; depletes glutathione levels by inhibiting synthesis. Induces ferroptosis in vitro.

Technical Data for L-Buthionine sulfoximine

M. Wt	222.3
Formula	C₈H₁₈N₂O₃S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	83730-53-4
PubChem ID	119565
InChi Key	KJQFBVYMGADDTQ-CVSPRKDYSA-N
Smiles	CCCC[S](=N)(=O)CC[C@H](N)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for L-Buthionine sulfoximine

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	22.23	100
	DMSO	22.23	100

Preparing Stock Solutions for L-Buthionine sulfoximine

The following data is based on the product molecular weight 222.3.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.50 mL	22.49 mL	44.98 mL
5 mM	0.90 mL	4.50 mL	9.00 mL
10 mM	0.45 mL	2.25 mL	4.50 mL
50 mM	0.09 mL	0.45 mL	0.90 mL

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Reconstitution Calculator

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References for L-Buthionine sulfoximine

References are publications that support the biological activity of the product.

Griffith Mechanism of action, metabolism, and toxicity of buthionine sulfoximine and its higher homologs, potent inhibitors of glutathione synthesis. J.Biol.Chem. 1982 PMID: 6128339
Yang Regulation of ferroptotic cancer cell death by GPX4. Cell. 2014 PMID: 24439385
Griffith & Meister Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine) J.Biol.Chem. 1979 PMID: 38242