L-NMMA acetate

Name: L-NMMA acetate
Brand: Tocris Bioscience
SKU: 0771

Tocris Bioscience, part of Bio-Techne | Catalog # 0771

Citations (8)

COA / SDS

Non-selective NOS inhibitor

Key Product Details

Description:	Non-selective NOS inhibitor
Chemical Name:	NG-Monomethyl-L-arginine acetate
Molecular Weight:	248.28

View Full Technical Details for L-NMMA acetate

Technical Data
Citations

Biological Activity for L-NMMA acetate

L-NMMA acetate is a competitive, irreversible inhibitor of all three NOS isoforms.

Technical Data for L-NMMA acetate

M. Wt	248.28
Formula	C₇H₁₆N₄O₂.CH₃CO₂H
Storage	Desiccate at RT
CAS Number	53308-83-1
PubChem ID	135242
InChi Key	IKPNWIGTWUZCKM-JEDNCBNOSA-N
Smiles	CC(O)=O.N=C(NCCC[C@H](N)C(O)=O)NC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for L-NMMA acetate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	12.41	50

Preparing Stock Solutions for L-NMMA acetate

The following data is based on the product molecular weight 248.28.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	8.06 mL	40.28 mL	80.55 mL
2.5 mM	1.61 mL	8.06 mL	16.11 mL
5 mM	0.81 mL	4.03 mL	8.06 mL
25 mM	0.16 mL	0.81 mL	1.61 mL

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Reconstitution Calculator

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References for L-NMMA acetate

References are publications that support the biological activity of the product.

Saksuma Identification of arginine as a precursor of endothelium-derived relaxing factor. Proc.Natl.Acad.Sci.U.S.A. 1988 PMID: 3263652
Rees Characterisation of three inhibitors of endothelial nitric oxide synthase in vivo and in vitro. Br.J.Pharmacol. 1990 PMID: 1706208
Reif and McCreedy N-nitro-L-arginine and N-monomethyl-L-arginine exhibit a differential pattern of inactivation toward the three nitric oxide synthases. Arch.Biochem.Biophys. 1995 PMID: 7540822
Olken Inactivation of macrophage nitric oxide synthase activity by N(G)-methyl-L-arginine. Biochem.Biophys.Res.Commun. 1991 PMID: 2049105