Lalistat 2

Name: Lalistat 2
Brand: Tocris Bioscience
SKU: 6099

Tocris Bioscience, part of Bio-Techne | Catalog # 6099

Citations (5)

COA / SDS

Selective LAL inhibitor

Key Product Details

Description:	Selective LAL inhibitor
Chemical Name:	4-(Piperidin-1-yl)-1,2,5-thiadiazol-3-yl piperidine-1-carboxylate
Purity:	≥98% (HPLC)
Molecular Weight:	296.39

View Full Technical Details for Lalistat 2

Technical Data
Citations

Biological Activity for Lalistat 2

Lalistat 2 is a selective lysosomal acid lipase inhibitor (IC₅₀ = 152 nM). Exhibits no inhibition of human pancreatic lipase or bovine milk lipoprotein lipase (up to 10 μM).

Compound Libraries for Lalistat 2

Lalistat 2 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Lalistat 2

M. Wt	296.39
Formula	C₁₃H₂₀N₄O₂S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1234569-09-5
PubChem ID	46867138
InChi Key	PNYYVHOTXOEBEV-UHFFFAOYSA-N
Smiles	O=C(N1CCCCC1)OC2=NSN=C2N3CCCCC3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Lalistat 2

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	29.64	100
	ethanol	29.64	100

Preparing Stock Solutions for Lalistat 2

The following data is based on the product molecular weight 296.39.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.37 mL	16.87 mL	33.74 mL
5 mM	0.67 mL	3.37 mL	6.75 mL
10 mM	0.34 mL	1.69 mL	3.37 mL
50 mM	0.07 mL	0.34 mL	0.67 mL

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Reconstitution Calculator

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References for Lalistat 2

References are publications that support the biological activity of the product.

Hamilton A new method for the measurement of lysosomal acid lipase in dried blood spots using the inhibitor Lalistat 2. Clin.Chim.Acta. 2012 PMID: 22483793
Rosenbaum Thiadiazole carbamates: potent inhibitors of lysosomal acid lipase and potential Niemann-Pick type C disease therapeutics. J.Med.Chem. 2010 PMID: 20557099
Rosenbaum Chemical screen to reduce sterol accumulation in Niemann-Pick C disease cells identifies novel lysosomal acid lipase inhibitors. Biochim.Biophys.Acta. 2009 PMID: 19699313