[Leu³¹,Pro³⁴]-Neuropeptide Y (human, rat)

Name: [Leu 31 ,Pro 34 ]-Neuropeptide Y (human, rat)
Brand: Tocris Bioscience
SKU: 1176
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1176

(1)

Citations (14)

COA / SDS

NPY Y1 receptor agonist

Key Product Details

Description:	NPY Y₁ receptor agonist
Alternative Names:	[Leu³¹,Pro³⁴]-NPY (human)
Purity:	≥95% (HPLC)
Molecular Weight:	4241

View Full Technical Details for [Leu³¹,Pro³⁴]-Neuropeptide Y (human, rat)

Technical Data
Citations / Reviews (1)

Biological Activity

[Leu³¹,Pro³⁴]-Neuropeptide Y (human, rat) is a high affinity neuropeptide Y Y₁ receptor agonist (K_i = 0.39 nM). Also shows affinity for Y₄ and Y₅ receptors.

Technical Data

M. Wt	4241
Formula	C₁₈₉H₂₈₄N₅₄O₅₆S
Single Letter Sequence	YPSKPDNPGEDAPAEDMARYYSALRHYINLLTRPRY (Modifications: Tyr-36 = C-terminal amide)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	132699-73-1
PubChem ID	24868223
InChi Key	MPWANDCMSKOYBR-MJWITIMHSA-N
Smiles	[H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

Soluble to 1mg/ml in water

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References

References are publications that support the biological activity of the product.

Michel XVI.International Union of Pharmacology recommendations for the nomenclature of neuropeptide Y, peptide YY, and pancreatic polypeptide receptors. Pharmacol.Rev. 1998 PMID: 9549761
Fuhlendorff [Leu³¹, Pro³⁴]Neuropeptide Y: a specific Y₁ receptor agonist. Proc.Natl.Acad.Sci.U.S.A. 1990 PMID: 2153286
Kask Evidence for involvement of neuropeptide Y receptors in the regulation of food intake: studies with Y₁-selective antagonist BIBP3226. Br.J.Pharmacol. 1998 PMID: 9723965
Bard Cloning and functional expression of a human Y₄ subtype receptor for pancreatic polypeptide, neuropeptide Y, and peptide YY. J.Biol.Chem. 1995 PMID: 7592911

[Leu³¹,Pro³⁴]-Neuropeptide Y (human, rat)

Tocris Bioscience, part of Bio-Techne | Catalog # 1176

Key Product Details

Biological Activity

Technical Data

Solubility

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References

Product Documents

COA

Certificate of Analysis

SDS

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[Leu31,Pro34]-Neuropeptide Y (human, rat)

Tocris Bioscience, part of Bio-Techne | Catalog # 1176

Key Product Details

Biological Activity

Technical Data

Solubility

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References

Product Documents

COA

Certificate of Analysis

SDS

[Leu³¹,Pro³⁴]-Neuropeptide Y (human, rat)