Liproxstatin-1 hydrochloride

Name: Liproxstatin-1 hydrochloride
Brand: Tocris Bioscience
SKU: 6113

Tocris Bioscience, part of Bio-Techne | Catalog # 6113

Citations (1)

COA / SDS

Potent ferroptosis inhibitor

Key Product Details

Description:	Potent ferroptosis inhibitor
Chemical Name:	N-[(3-Chlorophenyl)methyl]spiro[piperidine-4,2'(1'H)-quinoxalin]-3'-amine hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	377.31

View Full Technical Details for Liproxstatin-1 hydrochloride

Technical Data
Citations

Biological Activity for Liproxstatin-1 hydrochloride

Liproxstatin-1 hydrochloride is a potent ferroptosis inhibitor (IC₅₀ = 22 nM). Protects human renal proximal tubule cells from 1S,3R-RSL3 (Cat.No. 6118) -induced cell death in vitro. Inhibits acute renal failure and prolongs survival in Gpx4 knockdown mice. Also mitigates tissue damage in an in vivo hepatic ischemia/reperfusion model.

Compound Libraries for Liproxstatin-1 hydrochloride

Liproxstatin-1 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Liproxstatin-1 hydrochloride

M. Wt	377.31
Formula	C₁₉H₂₁ClN₄.HCl
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2250025-95-5
PubChem ID	134160236
InChi Key	HEHOHTKMIOBTKC-UHFFFAOYSA-N
Smiles	C1CNCCC12C(=NC3=CC=CC=C3N2)NCC4=CC(=CC=C4)Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Liproxstatin-1 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	37.73	100

Preparing Stock Solutions for Liproxstatin-1 hydrochloride

The following data is based on the product molecular weight 377.31.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.65 mL	13.25 mL	26.50 mL
5 mM	0.53 mL	2.65 mL	5.30 mL
10 mM	0.27 mL	1.33 mL	2.65 mL
50 mM	0.05 mL	0.27 mL	0.53 mL

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References for Liproxstatin-1 hydrochloride

References are publications that support the biological activity of the product.

Friedmann Angeli Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice. Nat.Cell.Biol. 2014 PMID: 25402683