LM22B 10

Name: LM22B 10
Brand: Tocris Bioscience
SKU: 6037

Tocris Bioscience, part of Bio-Techne | Catalog # 6037

Citations (6)

COA / SDS

TrkB and TrkC agonist; brain penetrant

Key Product Details

Chemical Name:	2,2',2',2'''-[[(4-Chlorophenyl)methylene]bis(4,1-phenylenenitrilo)]tetrakisethanol
Purity:	≥98%

View Full Technical Details for LM22B 10

Technical Data
Citations

Biological Activity for LM22B 10

LM22B 10 is a TrkB and TrkC agonist. Exhibits neurotrophic activity (EC₅₀ = 200-300 nM), improves survival and increases neurite outgrowth in hippocampal cells in vitro. Exhibits no significant activity in a screen of 57 other receptors and transporters. Inhibits binding of BDNF and neurotrophin-3 to TrkB and TrkC, respectively. Active in vivo and brain penetrant.

Technical Data for LM22B 10

Formula	C₂₇H₃₃ClN₂O₄
Storage	Store at -20°C
Purity	≥98%
CAS Number	342777-54-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for LM22B 10

Solubility

Soluble Soluble to 100 mM in DMSO and to 10 mM in ethanol

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References for LM22B 10

References are publications that support the biological activity of the product.

Yang T, Massa SM, Tran KC et al. A small molecule TrkB/TrkC neurotrophin receptor co-activator with distinctive effects on neuronal survival and process outgrowth. Neuropharmacology 2016-06-19 PMID: 27334657

LM22B 10

Tocris Bioscience, part of Bio-Techne | Catalog # 6037

Key Product Details

Biological Activity for LM22B 10

Technical Data for LM22B 10

Solubility for LM22B 10

Dilution Calculator

Reconstitution Calculator

References for LM22B 10

Product Documents for LM22B 10

COA

Certificate of Analysis

SDS

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