Lovastatin

Name: Lovastatin
Brand: Tocris Bioscience
SKU: 1530
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1530

(1)

Citations (36)

COA / SDS

Potent HMG-CoA reductase inhibitor

Key Product Details

Description:	Potent HMG-CoA reductase inhibitor
Alternative Names:	Mevinolin
Chemical Name:	(2S)-(1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl-2-methyl butanoate
Purity:	≥97% (HPLC)
Molecular Weight:	404.54

View Full Technical Details for Lovastatin

Technical Data
Citations / Reviews (1)

Biological Activity for Lovastatin

Lovastatin is a potent, competitive inhibitor of HMG-CoA reductase (K_i = 0.6 nM) therefore decreases cholesterol biosynthesis, in vitro and in vivo. Indirectly inhibits Rho-GTPase activity by depleting intracellular pool of isoprene residues. Decreases CDK2, 4, 6 and cyclin E levels and induces G1 arrest and apoptosis in tumor cell lines in vitro. Inactive lactam prodrug of lovastatin hydroxy acid, naturally bioactivated in vivo following oral administration.

Compound Libraries for Lovastatin

Lovastatin is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Lovastatin

M. Wt	404.54
Formula	C₂₄H₃₆O₅
Storage	Store at +4°C
Purity	≥97% (HPLC)
CAS Number	75330-75-5
PubChem ID	53232
InChi Key	PCZOHLXUXFIOCF-BXMDZJJMSA-N
Smiles	[H][C@]12[C@H](C[C@@H](C)C=C1C=C[C@H](C)[C@@H]2CC[C@@H]1C[C@@H](O)CC(=O)O1)OC(=O)[C@@H](C)CC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Lovastatin

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	20.23	50 with gentle warming
	DMSO	40.45	100

Preparing Stock Solutions for Lovastatin

The following data is based on the product molecular weight 404.54.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.47 mL	12.36 mL	24.72 mL
5 mM	0.49 mL	2.47 mL	4.94 mL
10 mM	0.25 mL	1.24 mL	2.47 mL
50 mM	0.05 mL	0.25 mL	0.49 mL

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Reconstitution Calculator

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References for Lovastatin

References are publications that support the biological activity of the product.

Ziegler Rho inhibition by lovas. affects apoptosis and DSB repair of primary human lung cells in vitro and lung tissue in vivo following fractionated irradiation. Cell Death Dis. 2017 PMID: 28796249
Alberts Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent. Proc.Natl.Acad.Sci.U.S.A. 1980 PMID: 6933445
Park Lovastatin-induced inhibition of HL-60 cell proliferation via cell cycle arrest and apoptosis. Anticancer Res. 1999 PMID: 10652602
Alberts Discovery, biochemistry and biology of lovas. Am.J.Cardiol. 1988 PMID: 3055919

Product Documents for Lovastatin

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.

SDS

⚠ WARNING: This product can expose you to chemicals including Lovastatin, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov